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Development of ductal adenocarcinoma during follow-up of branch-duct IPMNs
  1. S Crippa,
  2. R Salvia,
  3. C Bassi
  1. Department of Surgery, University of Verona, Policlinico “GB Rossi”, Verona, Italy
  1. Dr R Salvia, Chirurgia Generale B, Department of Surgery, “GB Rossi” Hospital, Piazzale LA Scuro, 10, University of Verona, 10-37134 Verona, Italy; roberto.salvia{at}

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We read with great interest the article by Uehara et al (Gut 2008;57:1561–5) supporting the development of ductal carcinoma during follow-up of branch-duct intraductal papillary mucinous neoplasms of the pancreas (BD-IPMNs). In a cohort of 60 patients, pancreatic ductal carcinoma distinct from IPMN developed in five cases (8%), while intraductal papillary mucinous carcinoma occurred in another two (3%). Uehara and colleagues found a 26-fold increase in the incidence of ductal adenocarcinoma in patients with BD-IPMNs compared with a control group without IPMNs. According to these data, during follow-up of BD-IPMNs the risk of development of ductal adenocarcinoma seems to be higher than the well-known possible “degeneration” of BD-IPMNs. Of note, even patients who undergo partial pancreatectomy for BD-IPMNs …

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  • Competing interests: None.

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