We thank Huang and Chen for their interest in our paper and agree that various growth hormones and cytokines can induce the activation of several signal pathways related to colorectal carcinogenesis in obesity. From a physiological viewpoint, the fact that adiponectin or other obesity-related factors do not exist in vivo alone but rather coexist in serum leads to the reasonable assumption that colorectal carcinogenesis may be influenced by the activation of several signal pathways. The purpose of our study was to elucidate the direct effect of adiponectin on colorectal epithelial cell proliferation and carcinogenesis promoted by a high-fat …