The authors would like to thank Ignjatovic and Saunders for their interest in our case report and acknowledge the vast experience of the St Mark’s group in this field. Their comments raise some important questions concerning the technical safety aspects of colonic endoscopic mucosal resection (EMR). These include: (1) the correct composition of submucosal mixture used for EMR (saline vs hyperviscus solutions, whether to add adrenaline and in what dose? Should a staining agent be used and if so which one?); (2) the quantity …