A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease

C Keywood; M Wakefield; J Tack

doi:10.1136/gut.2008.162040

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A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease

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	Abstract	Full	Pdf
May 2009	162	0	119
Jun 2009	96	0	104
Jul 2009	48	0	61
Aug 2009	208	36	107
Sep 2009	112	50	66
Oct 2009	180	31	58
Nov 2009	230	22	57
Dec 2009	125	18	31
Jan 2010	117	15	8
Feb 2010	123	30	9
Mar 2010	102	18	7
Apr 2010	112	29	12
May 2010	127	32	3
Jun 2010	124	25	4
Jul 2010	105	10	9
Aug 2010	108	12	14
Sep 2010	120	15	19
Oct 2010	110	18	17
Nov 2010	120	14	20
Dec 2010	108	14	16
Jan 2011	118	22	16
Feb 2011	105	26	21
Mar 2011	126	24	22
Apr 2011	116	4	20
May 2011	118	10	20
Jun 2011	125	7	11
Jul 2011	120	12	18
Aug 2011	113	7	13
Sep 2011	134	6	13
Oct 2011	144	15	20
Nov 2011	170	17	19
Dec 2011	152	15	20
Jan 2012	94	12	12
Feb 2012	104	9	10
Mar 2012	122	7	15
Apr 2012	133	19	13
May 2012	164	9	17
Jun 2012	159	6	9
Jul 2012	179	12	10
Aug 2012	178	5	8
Sep 2012	167	14	6
Oct 2012	172	8	8
Nov 2012	186	13	14
Dec 2012	180	6	6
Jan 2013	168	8	11
Feb 2013	149	11	6
Mar 2013	93	12	7
Apr 2013	48	10	8
May 2013	51	3	11
Jun 2013	71	9	8
Jul 2013	45	1	8
Aug 2013	52	1	1
Sep 2013	44	11	6
Oct 2013	50	4	6
Nov 2013	46	7	5
Dec 2013	11	13	13
Jan 2014	11	3	10
Feb 2014	19	1	3
Mar 2014	15	2	3
Apr 2014	17	7	14
May 2014	22	2	6
Jun 2014	18	3	7
Jul 2014	68	11	11
Aug 2014	68	9	7
Sep 2014	43	2	3
Oct 2014	51	1	5
Nov 2014	56	1	8
Dec 2014	72	1	5
Jan 2015	61	5	2
Feb 2015	53	3	6
Mar 2015	64	5	5
Apr 2015	49	5	2
May 2015	47	5	3
Jun 2015	51	5	8
Jul 2015	54	2	7
Aug 2015	48	7	9
Sep 2015	67	9	4
Oct 2015	40	5	4
Nov 2015	50	3	6
Dec 2015	49	3	6
Jan 2016	52	5	3
Feb 2016	33	6	4
Mar 2016	49	6	80
Apr 2016	42	4	13
May 2016	45	3	1
Jun 2016	56	3	8
Jul 2016	55	3	10
Aug 2016	53	3	2
Sep 2016	61	6	7
Oct 2016	60	2	3
Nov 2016	60	5	2
Dec 2016	57	3	3
Jan 2017	91	6	4
Feb 2017	50	2	6
Mar 2017	43	10	8
Apr 2017	37	24	9
May 2017	32	24	2
Jun 2017	48	15	2
Jul 2017	92	16	4
Aug 2017	80	18	0
Sep 2017	100	14	4
Oct 2017	89	11	1
Nov 2017	102	16	1
Dec 2017	92	16	4
Jan 2018	108	10	0
Feb 2018	76	14	1
Mar 2018	111	21	9
Apr 2018	58	22	5
May 2018	22	10	3
Jun 2018	46	24	0
Jul 2018	16	8	1
Aug 2018	21	15	3
Sep 2018	14	8	1
Oct 2018	12	6	1
Nov 2018	17	17	3
Dec 2018	6	6	1
Jan 2019	5	1	3
Feb 2019	14	10	6
Mar 2019	4	5	6
Apr 2019	4	4	8
May 2019	9	3	8
Jun 2019	10	7	10
Jul 2019	15	15	6
Aug 2019	14	13	6
Sep 2019	15	12	4
Oct 2019	9	9	8
Nov 2019	16	9	13
Dec 2019	12	10	4
Jan 2020	21	17	6
Feb 2020	16	11	4
Mar 2020	32	27	7
Apr 2020	13	9	4
May 2020	18	17	9
Jun 2020	30	30	8
Jul 2020	13	13	5
Aug 2020	15	10	10
Sep 2020	17	11	4
Oct 2020	29	23	2
Nov 2020	26	16	14
Dec 2020	19	15	5
Jan 2021	29	21	12
Feb 2021	6	5	0
Mar 2021	11	10	6
Apr 2021	6	6	2
May 2021	8	8	3
Jun 2021	14	14	6
Jul 2021	13	10	15
Aug 2021	11	11	11
Sep 2021	18	13	5
Oct 2021	16	11	22
Nov 2021	21	14	29
Dec 2021	25	16	8
Jan 2022	22	17	7
Feb 2022	26	20	5
Mar 2022	20	12	7
Apr 2022	33	24	8
May 2022	33	27	15
Jun 2022	24	22	5
Jul 2022	19	17	4
Aug 2022	38	31	8
Sep 2022	32	29	15
Oct 2022	34	34	11
Nov 2022	17	12	6
Dec 2022	19	15	5
Jan 2023	38	26	14
Feb 2023	34	30	5
Mar 2023	17	17	7
Apr 2023	8	8	8
May 2023	20	16	9
Jun 2023	10	4	2
Jul 2023	20	16	11
Aug 2023	9	7	7
Sep 2023	24	20	6
Oct 2023	13	12	5
Nov 2023	17	12	3
Dec 2023	19	17	6
Jan 2024	21	21	6
Feb 2024	20	20	10
Mar 2024	25	19	12
Total	10989	2187	2011

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