Article Text

Download PDFPDF
Screening for colorectal cancer: randomised trial comparing guaiac-based and immunochemical faecal occult blood testing and flexible sigmoidoscopy
  1. L Hol1,
  2. M E van Leerdam1,
  3. M van Ballegooijen2,
  4. A J van Vuuren1,
  5. H van Dekken3,
  6. J C I Y Reijerink4,
  7. A C M van der Togt5,
  8. J D F Habbema2,
  9. E J Kuipers1,6
  1. 1
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre Rotterdam, The Netherlands
  2. 2
    Department of Public Health, Erasmus MC University Medical Centre Rotterdam, The Netherlands
  3. 3
    Department of Pathology, Erasmus MC University Medical Centre Rotterdam, The Netherlands
  4. 4
    Cancer Screening Organisation for Southwest Netherlands, Vlaardingen, The Netherlands
  5. 5
    Comprehensive Cancer Centre, Rotterdam, The Netherlands
  6. 6
    Department of Internal Medicine, Erasmus MC University Medical Centre Rotterdam, The Netherlands
  1. Correspondence to Dr L Hol, Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Centre Rotterdam, ‘s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands; l.hol.1{at}erasmusmc.nl

Footnotes

  • Funding This trial was funded by the Dutch Cancer Society (EMCR 2006-3673), the Dutch Ministry of Health, Health Care Prevention Program–Implementation (ZonMw 2006-5877), Olympus Medical Systems Europe GmbH, Hamburg, Germany and Eiken Chemical Co., Tokyo, Japan.

  • Competing interests None.

  • Ethics approval The study was approved by the Dutch Ministry of Health (2006/02WBO). The approval included the pre-randomisation design. The study letters and information brochures were approved by the Institutional Review Board of the Erasmus MC (MEC-2005-264).

  • Study organisation

    EJ Kuipers, JDH Habbema and M van Ballegooijen conceived the idea for the study; EJ Kuipers, JDH Habbema, M van Ballegooijen and ME van Leerdam designed the protocol; EJ Kuipers and JDH Habbema supervised the execution of the study; L Hol performed the retrieval of the population sample and the randomisation in collaboration with Tenalea, Amsterdam; JCIY Reijerink was responsible for the retrieval of the target population from the municipal registries and all mailings; AJ van Vuuren was responsible for the analyses of the FOBTs; ME van Leerdam was responsible for the endoscopy programme; H van Dekken evaluated all pathology samples of the sigmoidoscopies. JCIY Reijerink, ME van Leerdam and L Hol were responsible for the database design; L Hol was responsible for data entry; ACM van der Togt coordinated the daily process. L Hol drafted the report; L Hol and C Looman performed the statistical analyses; all the collaborators listed above were given an opportunity to comment on the paper.

    Trial steering committee

    L Hol, ME van Leerdam, M van Ballegooijen, AJ van Vuuren, JCIY Reijerink, ACM van der Togt, JDF Habbema and EJ Kuipers.

    Trial advisory board

    JW Coebergh, A Cats and IMA Joung.

  • Provenance and Peer review Not commissioned; externally peer reviewed.

View Full Text

Statistics from Altmetric.com

Footnotes

  • Funding This trial was funded by the Dutch Cancer Society (EMCR 2006-3673), the Dutch Ministry of Health, Health Care Prevention Program–Implementation (ZonMw 2006-5877), Olympus Medical Systems Europe GmbH, Hamburg, Germany and Eiken Chemical Co., Tokyo, Japan.

  • Competing interests None.

  • Ethics approval The study was approved by the Dutch Ministry of Health (2006/02WBO). The approval included the pre-randomisation design. The study letters and information brochures were approved by the Institutional Review Board of the Erasmus MC (MEC-2005-264).

  • Study organisation

    EJ Kuipers, JDH Habbema and M van Ballegooijen conceived the idea for the study; EJ Kuipers, JDH Habbema, M van Ballegooijen and ME van Leerdam designed the protocol; EJ Kuipers and JDH Habbema supervised the execution of the study; L Hol performed the retrieval of the population sample and the randomisation in collaboration with Tenalea, Amsterdam; JCIY Reijerink was responsible for the retrieval of the target population from the municipal registries and all mailings; AJ van Vuuren was responsible for the analyses of the FOBTs; ME van Leerdam was responsible for the endoscopy programme; H van Dekken evaluated all pathology samples of the sigmoidoscopies. JCIY Reijerink, ME van Leerdam and L Hol were responsible for the database design; L Hol was responsible for data entry; ACM van der Togt coordinated the daily process. L Hol drafted the report; L Hol and C Looman performed the statistical analyses; all the collaborators listed above were given an opportunity to comment on the paper.

    Trial steering committee

    L Hol, ME van Leerdam, M van Ballegooijen, AJ van Vuuren, JCIY Reijerink, ACM van der Togt, JDF Habbema and EJ Kuipers.

    Trial advisory board

    JW Coebergh, A Cats and IMA Joung.

  • Provenance and Peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles