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  1. Emad El-Omar,
  2. Severine Vermeire,
  3. Alexander Gerbes

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Seven-microRNA signature and prediction of gastric cancer survival

MicroRNAs are a wide class of small, non-coding RNAs that negatively regulate protein expression at the post-transcriptional level. MicroRNAs regulate the expression of hundreds of their target genes, thereby controlling a wide range of biological functions such as cellular proliferation, differentiation and apoptosis. Disruption of the physiological expression patterns of micro-RNAs is associated with several examples of human tumorigenesis. In this study by Li et al microRNA expression profile was analysed by real-time RT-PCR in 100 patients with gastric cancer, and Cox proportional hazard regression and risk-score analysis were used to identify a stage-independent set of seven-microRNA signatures. This microRNA signature was further validated in an independent cohort of 60 patients. Multivariate analysis showed that the risk signature was an independent predictor of overall survival (HR=3.046; 95% CI 1.246 to 7.445, p=0.015) and relapse-free survival (HR=3.337; 95% CI 1.298 to 8.580, p=0.012) (figure). This prognostic signature could be applicable to future decisions about treatment. See page 579.

Kaplan–Meier estimates of overall survival and relapse-free survival according to the seven-microRNA signature.

Levofloxacin or clarithromycin for first- or second- line H pylori regimens

Which antibiotic is better to use first: levofloxacin (LAL) or clarithromycin (CAL)? This question was answered by Wu et al in a randomised comparative trial with crossover design. Eligible patients were randomised to receive LAL …

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