Article Text

Download PDFPDF
Increased colorectal cancer risk in first-degree relatives of patients with hyperplastic polyposis syndrome
  1. K S Boparai1,
  2. J B Reitsma2,
  3. V Lemmens3,
  4. T A M van Os4,
  5. E M H Mathus-Vliegen1,
  6. J J Koornstra5,
  7. F M Nagengast6,
  8. L P van Hest7,
  9. J J Keller1,
  10. E Dekker1
  1. 1Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
  2. 2Department of Clinical Epidemiology & Biostatistics, Academic Medical Center, Amsterdam, The Netherlands
  3. 3Department of Research, Comprehensive Cancer Centre South, Eindhoven, The Netherlands
  4. 4Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands
  5. 5Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, The Netherlands
  6. 6Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands
  7. 7Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands
  1. Correspondence to Dr E Dekker, Department of Gastroenterology and Hepatology, Academic Medical Center Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands; e.dekker{at}


Introduction Hyperplastic polyposis syndrome (HPS) is characterised by the presence of multiple colorectal hyperplastic polyps and is associated with an increased colorectal cancer (CRC) risk. For first-degree relatives of HPS patients (FDRs) this has not been adequately quantified. Reliable evidence concerning the magnitude of a possible excess risk is necessary to determine whether preventive measures, like screening colonoscopies, in FDRs are justified.

Aims and methods We analysed the incidence rate of CRC in FDRs and compared this with the general population through person-year analysis after adjustment for demographic characteristics. Population-based incidence data from the Eindhoven Cancer Registry during the period 1970–2006 were used to compare observed numbers of CRC cases in FDRs with expected numbers based on the incidence in the general population.

Results A total of 347 FDRs (41% male) from 57 pedigrees were included, contributing 11 053 person-years of follow-up. During the study period, a total of 27 CRC cases occurred among FDRs compared to five expected CRC cases (p<0.001). The RR of CRC in FDRs compared to the general population was 5.4 (95% CI 3.7 to 7.8). Four FDRs satisfied the criteria for HPS. Based on the estimated HPS prevalence of 1:3000 in the general population the projected RR of HPS in FDRs was 39 (95% CI 13 to 121).

Conclusions FDRs of HPS patients have an increased risk for both CRC and HPS compared to the general population. Hence, as long as no genetic substrate has been identified, screening colonoscopies for FDRs seem justified but this needs to be prospectively evaluated.

  • Hyperplastic polyposis syndrome
  • colorectal cancer
  • first-degree relatives
  • polyposis

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Competing interests None.

  • Ethics approval This study was conducted in accordance with the research code of our institutional medical ethical committee on human experimentation, as well as in agreement with the Helsinki Declaration of 1975, as revised in 1983.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Linked Articles

  • Digest
    Emad El-Omar Severine Vermeire Alexander Gerbes