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OC-090 To determine the negative predictive value of faecal calprotectin in predicting future organic gastrointestinal disease
  1. J K Moore,
  2. S West,
  3. S Kelly,
  4. G Robins
  1. Department of Gastroenterology, York District General Hospital, York, UK


Introduction Faecal calprotectin (FC) levels can be used to predict the likelihood of relapse in patients with inflammatory bowel disease (IBD)1 and as a non-invasive marker to predict organic gastrointestinal disease (OGID)2 However, long-term follow-up of patients with low FC levels has not been done. Our aim was to determine whether patients with low FC levels develop OGID over a 5-year period.

Methods York Hospital serves a population of approximately 280 000 and has measured FC where clinically indicated in patients since 2004. Records of patients with a normal FC (<50 μg/g) in 2004 were examined retrospectively. Those with known OGID at the time of index FC measurement were excluded. Primary outcome was diagnosis of an OGID (eg, colorectal cancer or polyps >1 cm, IBD) in the 5 years subsequent to the index FC measurement. The assay used was the PhiCal Calprotectin Elisa kit with a clinical sensitivity of 74% and specificity of 84% at 50 μg/g.3

Results 118 patients (39 male and 79 female) were identified. The mean age was 40.4 years (SEM 1.3); median age was 41 years (range 15–83). The mean FC level was 13.95 μg/g (SEM 1.04). The median was 10 μg/g (range 5–48). 84 patients were diagnosed with Functional Bowel Disease. No patients during the 5-year follow-up period developed OGID.

Conclusion A normal FC has an extremely high negative predictive value for developing OGID over the subsequent 5 years.

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