Table of contents

BASL abstracts

• Clinical hepatology: OP01 Alcohol and liver disease detection study ALDDeS: early results and implications (16 November, 2010) Free

  N Sheron, N Sheron, M Moore, P Roderick, W O'Brian, G Leydon, C Bowerman
• Clinical hepatology: OP02 Prevalence and severity of nonalcoholic fatty liver disease in a large prospective primary care cohort with abnormal liver function tests (16 November, 2010) Free

  M Armstrong, D Houlihan, L Bentham, J Shaw, S Olliff, J Neuberger, R Lilford, P Newsome
• Clinical hepatology: OP03 Effects of two years of liraglutide treatment on fatty liver disease in patients with type 2 diabetes: analysis of the Liraglutide Effect and Action in Diabetes-2 extension trial (16 November, 2010) Free

  M Armstrong, A Falahati, D D Houlihan, B Elbrand, W E Schmidt, S Gough, P N Newsome
• Clinical hepatology: OP04 Circulating levels of the long pentraxin PTX3, but not hepatocyte derived C-reactive protein, correlate with severity following human acute liver injury (16 November, 2010) Free

  D Craig, P Lee, E A Pryde, S Walker, G Beckett, P Hayes, K Simpson
• Clinical hepatology: OP05 Medium term outcome of de novo autoimmune hepatitis after liver transplantation in children; a single centre experience (16 November, 2010) Free

  M Hii, A Grammatikopoulus, N Hadzic, M Rela, G Mieli-Vergani, D Vergani
• Clinical hepatology: OP06 Tim3 down-regulation renders CD4 effector cells less susceptible to T-reg control in patients with autoimmune hepatitis (16 November, 2010) Free

  R Liberal, Y Ma, G Mieli-Vergani, M Longhi
• Basic science: OP07 Macrophage cell therapy causes the hepatic recruitment of host effector cells and improves structure and function in a murine model of chronic liver disease (16 November, 2010) Free

  J Thomas, D Wojtacha, C Pope, T Gordon-Walker, A Robson, S Hartland, P Ramachandran, J Iredale, S Forbes
• Basic science: OP08 Evidence for early astrocyte activation, cellular stress and compensatory microglial related transforming growth factor-α responses in bile-duct ligated rats (16 November, 2010) Free

  G Wright, G Wright, T Newman, Y Sharifi, N Davis, R Jalan
• Basic science: OP09 The development and testing of the University College London liver support device (UCL-ARSeNEL): improvement of survival in paracetamol-induced acute liver failure pigs (16 November, 2010) Free

  K Thiel, A Proven, N Davies, P Leckie, K Thiel, R Frieg, M Storr, A Koenigsrainer, M Schenk
• Basic science: OP10 Relaxin inhibits human myofibroblast contractility and modulates portal hypertension in vivo (16 November, 2010) Free

  J Fallowfield, A Hayden, R Aucott, J Schrader, T Gordon-Walker, D Mole, J Collins, J Iredale
• Viral hepatitis: OP11 Final results from telaprevir phase II studies in genotype 1 treatment-naive or experienced subjects with chronic hepatitis C (16 November, 2010) Free

  G F Foster, G Dusheiko, C Hezode, P Marcellin, J McHutchison, M Beumont, B Kauffman
• Viral hepatitis: OP12 UK experience of treatment of chronic viral hepatitis C in children and adolescents: predictors of viral response and quality of life (16 November, 2010) Free

  M Abdel-Hady, S Bansal, S Davison, M Brown, S Tizzard, S Mulla, P Davies, G Mieli-Vergani, D Kelly
• Viral hepatitis: OP13 Spontaneous resolution of acute hepatitis C virus infection correlates with the reconstitution of the circulating Cd56dim natural killer-cell pool (16 November, 2010) Free

  A Riva, A Riva, S Phillips, A Evans, A Ambrozaitis, R Williams, N V Naoumov, S Chokshi
• Viral hepatitis: OP14 Measurement of low density apolipoprotein B associated hepatitis C virus lipoviral particles in genotype 1 infection is more clinically relevant than total viral load (16 November, 2010) Free

  D Sheridan, S Bridge, D A Sheridan, D Felmlee, H Thomas, S Taylor-Robinson, R Dermot, G Neely, G L Toms, M F Bassendine
• Transplant: OP15 Early biliary complications after liver transplantation: incidence, risk factors and centre effect (16 November, 2010) Free

  M Dawwas, A Gimson
• Clinical hepatology: OP16 Evidence for compartmentalised endotoxaemia and its effect on neutrophil function in the portal circulation in cirrhosis (16 November, 2010) Free

  J Macnaughtan, N Davies, V Stadlbauer, S Olde Damink, R Mookerjee, R Jalan
• Clinical hepatology: OP17 Clinical effect of albumin dialysis in patients with intractable pruritus correlates closely with changes in autotaxin activity but not bile salt levels (16 November, 2010) Free

  P Leckie, G Tritto, A E Kremer, G Tritto, R P Mookerjee, N Davies, D Jones, R P J Oude Elferink, R Jalan, U Beuers
• Clinical hepatology: OP18 Abnormal liver histology in patients taking methotrexate correlates poorly with dosage or duration of therapy and reflects established risk factors for steatohepatitis (16 November, 2010) Free

  R Aspinall, A Joshi, A Godkin, K Roberts, G Williams
• Basic science: OP19 Differential expression of microRNAs during hepatic stellate cell activation and their role in the regulation of hepatic stellate cell proliferation and apoptosis (16 November, 2010) Free

  A J Fowell, T Sanchez-Elsner, R C Benyon, W M Rosenberg, J E Collins
• Basic science: OP20 Hepatocytes and cholangiocytes do not have significant telomere shortening with increasing chronological age in normal livers (16 November, 2010) Free

  S Verma, P Tachtazisis, S Penrhyn-Lowe, C Scarpini, N Coleman, G Alexander
• Basic science: OP21 The role of Toll like receptor-4 in the pathogenesis of hepatorenal syndrome in a Bile duct ligated model of cirrhosis in the rat (16 November, 2010) Free

  N Shah, D Dhar, F Mohamed, R Mookerjee, N A Davies, R Jalan
• Basic science: OP22 A significant reduction in “pro-inflammatory” CD14lo/CD16hi monocytes in paracetamol-induced acute liver failure: association with outcome and CCR2 expression (16 November, 2010) Free

  D Abeles, C G Antoniades, M S Longhi, N J Taylor, D L Shawcross, G Auzinger, W Bernal, N Heaton, J A Wendo, D Vergani
• Viral hepatitis: OP23 Vascular endothelial growth factor activation of liver sinusoidal endothelial cells via vascular endothelial growth factor receptor-2 regulates hepatocellular hepatitis C virus replication (16 November, 2010) Free

  I Rowe, P Lalor, D Adams, P Balfe, J McKeating
• Viral hepatitis: OP24 Chronic hepatitis B virus infection in the UK: a multicentre study of clinical and virological characteristics (16 November, 2010) Free

  L Fries, A Rodger, S Ijaz, S Moreea, A Bathgate, T Wong, W Rosenberg, M Bassendine, P Mills, S Ryder, D Mutimer, G Dusheiko, M Jacobs, J Dillon, M Anderson, J Collier, H Hussaini, G Bird, R Tedder, G Rosenberg, J Banatvala, R Williams, N Naoumov, S Chokshi, M Thursz, A Johnson
• Transplant: OP25 Bacterial translocation and regulatory T lymphocytes in patients with liver cirrhosis (16 November, 2010) Free

  M Márquez, M Montes de Oca, C Rodríguez-Ramos, C Fernández-Gutiérrez, M J Blanco, S P Corchado, J A Girón
• Transplant: OP26 Predicting thrombotic complications after liver transplantation in patients with Budd Chiari syndrome (16 November, 2010) Free

  R Westbrook, R Westbrook, D Orr, N Heaton, J O'Grady, R Patel, N Lea, A Quaglia, A Pagliuca, R Arya, G Mufti, M Heneghan
• Clinical hepatology: P01 UDCA response criteria identify a sub-group of PBC patients with an inherently good prognosis rather than a specific disease response (16 November, 2010) Free

  I Patanwala, J Newton, D Jones
• Clinical hepatology: P02 Impaired subendocardial myofibre function in primary biliary cirrhosis (16 November, 2010) Free

  I Patanwala, K Hollingsworth, J Newton, I Patanwala, R Taylor, A Blamire, D Jones
• Clinical hepatology: P03 The use of BRUM1 resequencing microarray to identify mutations in patients with neonatal cholestasis (16 November, 2010) Free

  J Hartley, C Bruce, R Brown, K McKay, U Bauman, E Sturm, B Udd, P Mckiernan, D McMullen, J Mansson, F McDonald, E Maher, A Knisely, C Hendriksz, D Kelly, P Gissen
• Clinical hepatology: P04 Admission serum lactate is a strong predictor of outcome in cirrhotics admitted to intensive care unit, and when added to the liver-specific scores of model for end-stage liver disease or UK model for end-stage liver disease, improves their respective predictive value (16 November, 2010) Free

  A Burroughs, M Garcovich, V Vemala, B Agarwal, A Davenport, S Shaw, J O'Beirne, A Burroughs
• Clinical hepatology: P05 B-cell epitope mapping of anti-ro-52 responses in patients with primary biliary cirrhosis (16 November, 2010) Free

  M G Mytilinaiou, W Meyer, L Komorowski, C Probst, E Davies, D Vergani, D Bogdanos
• Clinical hepatology: P06 Hepatic lumican expression in paediatric non-alcoholic fatty liver disease (16 November, 2010) Free

  E Fitzpatrick, R Mitry, A Quaglia, A Dhawan
• Clinical hepatology: P07 Splanchnic steal in patients with liver disease: a 3T MRI study of visceral blood flow (16 November, 2010) Free

  N McAvoy, K A Leyland, J M J Richards, S I K Semple, D Patel, D E Newby, P C Hayes
• Clinical hepatology: P08 People with diabetes have a higher risk of death from liver disease compared to the general population (16 November, 2010) Free

  J Parkes
• Clinical hepatology: P09 Hepatocellular carcinoma in primary biliary cirrhosis: defining risk in an era of ursodeoxycholic acid use (16 November, 2010) Free

  J Maggs, J O'Grady, N Heaton, V Aluvihare, A Quaglia, K Agarwal, M Heneghan, A Suddle
• Clinical hepatology: P10 High troponin I in acute liver failure: a marker of myocardial injury or metabolic stress? (16 November, 2010) Free

  V Audimoolam, J Wendon, W Bernal, C Willars, M Mcphail, G Auzinger
• Clinical hepatology: P11 Retrospective analysis to identify the incidence and prevalence of pre-existing chronic liver disease in patients presenting with hyperacute, acute and sub-acute liver failure (16 November, 2010) Free

  V Audimoolam, Y Zen, D Joshi, W Bernal, G Auzinger, C Willars, B Portman, N Heaton, J O'Grady, M Heneghan, K Agarwal, V Aluvihare, A Suddle, J Wendon
• Clinical hepatology: P12 A pragmatic traffic light system for triage of liver disease: results in a cohort of 710 subjects (16 November, 2010) Free

  N Sheron, S Harris, M Moore, E Williams, M Ledbury, W Mackintosh, L Kramer, N Kapoor, N Johari, A Watts, A Bateman
• Clinical hepatology: P13 Allo- and auto-antibody responses in alcoholic liver disease as biomarkers of prognosis (16 November, 2010) Free

  I Patanwala, J Palmer, E Henderson, C Day, D Jones
• Clinical hepatology: P14 Mycophenolate mofetil in patients with autoimmune hepatitis intolerant to azathioprine (16 November, 2010) Free

  D Jothimani, D Jothimani, U Warshow, A Barnardo, M Cramp, J Mitchell, T Cross
• Clinical hepatology: P15 Non-invasive assessment of hepatic fibrosis in prior non-responders to hepatitis C virus treatment—a comparison of eight marker panels of liver fibrosis (16 November, 2010) Free

  S Tanwar, E Ellis, C Herold, W Rosenberg
• Clinical hepatology: P16 Non-invasive detection of oesophageal varices: comparison of non-invasive assessment of systemic haemodynamics with laboratory parameters and predictive scores (16 November, 2010) Free

  K Rye, G Mortimore, A Austin, J Freeman
• Clinical hepatology: P17 Anticoagulation for liver fibrosis: a pilot study in hepatitis C infected patients (16 November, 2010) Free

  A Dhar, Q Anstee, J Cobbold, J Stove, A Martinelli, S Taylor-Robinson, M Thursz
• Clinical hepatology: P18 The impact of Health Protection Agency guidelines on the management of hepatitis B in West Kent (16 November, 2010) Free

  I Coltart, J Petersen-Camp, M Holland, G Bird
• Clinical hepatology: P19 Serum creatinine underestimates renal function in patients with cirrhosis as compared to patients with organic renal disease (16 November, 2010) Free

  A Burroughs, M Garcovich, E Tsochatzis, D Georgadis, G Germani, G Fede, A Davenport, J O'Beirne, A Burroughs
• Clinical hepatology: P20 Functional capacity is significantly impaired in primary biliary cirrhosis and related to orthostatic symptoms (16 November, 2010) Free

  I Patanwala, J Newton, I Patanwala, C Elliot, J Frith, C Ghazala, J Pariman, D Jones
• Clinical hepatology: P21 The evaluation of serum ferritin and trasferrin saturation in the diagnosis of haemochromatosis in an ethnically diverse population (16 November, 2010) Free

  S Al-shamma, S Khaled, P Kennedy, A Provan
• Clinical hepatology: P22 Derangements in energy, amino-acid and gut microbial metabolism in hepatic encephalopathy: a metabolomic approach (16 November, 2010) Free

  J Bajaj, N Patel, D Heuman, A Sanyal, D Bell
• Clinical hepatology: P24 Cytokine biomarker profiling in acetaminophen-induced acute liver failure: importance of monocyte chemotactic protein-1 in prognosis and hepatic encephalopathy (16 November, 2010) Free

  H Antoniades, B Mathew, M McPhail, R Srirajaskanthan, P Berry, W Bernal, M Hussain, G Auzinger, J Wendon
• Clinical hepatology: P25 Quantitative comparison of microbubble ultrasound techniques for the assessment of hepatic fibrosis in chronic hepatitis C (16 November, 2010) Free

  J Cobbold, D Patel, J F L Cobbold, J Fitzpatrick, M M E Crossey, N Patel, H C Thomas, S D Taylor-Robinson
• Clinical hepatology: P26 Hepatocellular carcinoma surveillance in patients with established cirrhosis: the Birmingham experience (16 November, 2010) Free

  H Bridgestock, R Desai, J Neuberger
• Clinical hepatology: P27 Neutrophil dysfunction: the missing link between ammonia, infection and hepatic encephalopathy? (16 November, 2010) Free

  N Taylor, A Nishtala, F Lin, R D Abeles, J O'Grady, J Wendon, Y Ma, D Shawcross
• Clinical hepatology: P28 Optimising the analysis of the electroencephalogram in hepatic encephalopathy (16 November, 2010) Free

  M Morgan, H Dabrowski, M Stubbs, C Jackson
• Clinical hepatology: P29 Do disturbances in cerebral oscillatory networks explain sleep and neuropsychiatric abnormalities in patients with cirrhosis? (16 November, 2010) Free

  M Morgan, M Stubbs, H Dabrowski, C Jackson
• Clinical hepatology: P30 Cytoplasmic expression of Toll-like receptor-9 is associated with increased cellular proliferation in hepatocellular carcinoma (16 November, 2010) Free

  F Mohamed, D Dhar, A Winstanley, N Shah, S Behboudi, R Mookerjee, S O Damink, N Davies, R Jalan
• Clinical hepatology: P31 Pattern and significance of biochemical abnormalities in referrals to a NAFLD clinic (16 November, 2010) Free

  G Masterton, P Hayes
• Clinical hepatology: P32 Gut sterilisation with norfloxacin modulates cerebral inflammation in cirrhosis and prevents deterioration in brain oedema and delays coma in cirrhotic rats (16 November, 2010) Free

  N Shah, D Dhar, R P Mookerjee, N A Davies, R Jalan
• Basic science: P33 Treatment with Toll-like receptor 4 antagonist restores the inflammatory cellular immune dysfunction in acetaminophen induced acute liver failure mice (16 November, 2010) Free

  N Shah, M Montes de Oca, N Shah, D Dhar, M Jover-Cobos, N Alun Davies, R Mookerjee, R Jalan
• Basic science:

  P34 The mechanism behind synergistic action of l-ornithine and phenylacetate to reduce ammonia in bile-duct ligation rats

  (16 November, 2010) Free

  M Jover, M L Noiret, A Habtesion, V Balasubramaniyan, Y Sharifi, Manuel Romero-Gomez, N A Davies, R Jalan
• Basic science: P35 Treatment with an Alpha 2a Adrenoreceptor Antagonist Modulates Hepatic Inflammation, Markedly Reduces Portal Pressure, and Improves Arterial Pressure and Hepatic Blood Flow in Cirrhotic Rats (16 November, 2010) Free

  N Shah, M Montes de Oca, N Shah, D Dhar, M Jover-Cobos, N Alun Davies, R Mookerjee, R Jalan
• Basic science: P36 Block of interferon γ and co-culture with smDCs enhance antigen-specific T-reg suppression ability in autoimmune hepatitis type 2 (16 November, 2010) Free

  M S Longhi, G Mieli-Vergani, Y Ma, D Vergani
• Basic science: P37 Development of a Stable, Clinically Relevant, Fully Monitored and Managed Reproducible Model of Paracetamol Induced Acute Liver Failure in the Pig (16 November, 2010) Free

  A Proven, C Thiel, P Leckie1, K Thiel, M Schenk, R Jalan, N Davies
• Basic science: P38 Matrix stiffness regulates proliferation, differentiation and chemotherapeutic responsiveness in hepatocellular carcinoma (16 November, 2010) Free

  T Gordon-Walker, J Schrader, D Benten, M Van Deemter, S J Forbes, R G Wells, J P Iredale
• Basic science: P40 Ex vivo treatment of neutrophils with a p38-MAPK agonist in patients with liver failure improves their bacteriocidal capacity (16 November, 2010) Free

  D Shawcross, A Nishtala, N J Taylor, J A Wendon
• Basic science: P41 Genetic variation in biliary transporters as a susceptibility factor for cholangiocarcinoma (16 November, 2010) Free

  C Wadsworth, P Dixon, J Wong, M Chapman, S McKay, A Sharif, D Spalding, S Pereira, H Thomas, S Taylor-Robinson, J Whittaker, C Williamson, S Khan
• Basic science: P42 Cholestatic pregnancy alters cholesterol and lipid transport to the fetal circulation, affecting lipid metabolism of the fetus (16 November, 2010) Free

  G Papacleovoulou, A Milona, B Owen, E Jansen, C Williamson
• Basic science: P43 Adhesion of human bone marrow-derived mesenchymal stem cells to liver sinusoidal endothelium is both CD29 and CD44 dependant, whilst initial tethering of MSCs to endothelium involves CD29 but not CD44 (16 November, 2010) Free

  V Aldridge, A Garg, J Youster, P Newsome
• Basic science: P44 A Wnt-NUMB-Notch axis is required for lineage separation of hepatic progenitor cells in the regenerating cells in the regenerating adult liver of mouse and human (16 November, 2010) Free

  L Boulter, T G Bird, O Govaere, J P Iredale, O Sansom, S Lowell, T Roskams, S J Forbes
• Basic science: P45 The effect of SUMO modification on hepatic differentiation from human embryonic stem cells (16 November, 2010) Free

  Z Hannoun, E Jaffray, S Greenhough, I Wilmut, J P Iredale, R T Hay, D C Hay
• Basic science: P46 Vascular adhesion protein-1 promotes inflammation and fibrogenesis in murine steatohepatitis (16 November, 2010) Free

  L C Claridge, C J Weston, E L Haughton, N Westerlund, P F Lalor, D J Smith, D H Adams
• Basic science: P47 CLEVER-1 mediates T regulatory cell recruitment via hepatic sinusoidal endothelium by transcellular migration (16 November, 2010) Free

  S Shetty, C Weston, Y Oo, N Westerlund, Z Stamataki, J Youster, S Hubscher, M Salmi, S Jalkanen, P Lalor, D H Adams
• Basic science: P48 Haematopoietic but not mesenchymal stem cells contribute to the stromal microenvironment in cholangiocarcinoma and do not transdifferentiate into malignant bile ducts (16 November, 2010) Free

  A Robson, K Samuel, A Pellicoro, J Iredale, S Forbes
• Basic science: P49 The stromal compartment of hepatocellular carcinoma promotes the local differentiation of tolerogenic dendritic cells (16 November, 2010) Free

  A Bhatt, S M Curbishley, E L Haughton, C J Weston, M Blahova, D H Adams
• Basic science: P50 Synthetic lethality in liver cancer cell lines treated with inhibitors of DNA double-strand break repair (16 November, 2010) Free

  H Reeves, L Cornell, J Munck, F Budhisetiawan, D Newell, J Bardos, D Manas, C Nicola, H Reeves
• Basic science: P51 Inadequate compensation by glutamine synthetase and increased glutaminase activity contributes to hyperammonaemia in cirrhosis (16 November, 2010) Free

  M Jover, L Noiret, A Habtesion, V Balasubramaniyan, Y Sharifi, M Romero-Gomez, N Davies, R Jalan
• Basic science: P52 Neutrophil dysfunction: a potential biomarker of poor prognosis in acute liver failure? (16 November, 2010) Free

  N Taylor, A Nishtala, F Lin, R D Abeles, W Bernal, J Wendon, Y Ma, D Shawcross
• Basic science: P53 The contrasting effect of octanoate and oleate on phosphatase and tensin homologue expression in in vitro model of steatosis using HepG2/C3A cells (16 November, 2010) Free

  K A Lockman, N Plevris, C Pemberton, P Cowan, P Lee, A Pryde, P C Hayes, C Filippi, J N Plevris
• Basic science: P54 Vascular adhesion protein-1: a key player in the modulation of hepatic fibrosis (16 November, 2010) Free

  C Weston, E L Haughton, N M Westerlund, L C Claridge, J Pravin, D J Smith, D H Adams
• Basic science: P55 Syngenic bone marrow transfer stimulates hepatic progenitor cell expansion via TWEAK/Fn14 Signalling: implications for human autologous cell therapy (16 November, 2010) Free

  T Bird, B Knight, L Boulter, S Gordon-Keylock, D Wjotacha, J Thomas, O Sansom, J Iredale, S Forbes
• Basic science: P56 Factor Xa inhibition suppresses thioacetamide induced liver fibrosis (16 November, 2010) Free

  A Dhar, Q Anstee, F Sadiq, A Levene, R Goldin, M Thursz
• Basic science: P57 Administration of branched chain amino acids to hyperammonemic cirrhotic animals is associated with worsening of hyperammonemia and increase in brain oedema (16 November, 2010) Free

  Y Sharifi, J Maria, L Noiret, A Habtesion, N Davies, R Jalan
• Basic science: P58 Evidence of dendritic cell dysfunction in cirrhosis and its restoration by Toll-like receptor 4 antagonism (16 November, 2010) Free

  N Shah, M Montes de Oca, N Shah, D Dhar, N Davies, R P Mookerjee, M Jover-Cobos, A Habtesion, R Jalan
• Basic science: P59 TLR4 antagonist in acute liver failure: a novel therapeutic strategy (16 November, 2010) Free

  N Shah, D Dhar, M Montes de Oca, M Jover-Cobos, N Davies, F Mohamed, R P Mookerjee, R Jalan
• Basic science: P60 Acute lowering of portal pressure in cirrhotic rats by Anti-TNF therapy is associated with reduced NFkB-driven inflammation and improved eNOS function through the asymmetric dimethylarginine-dimethylarginine-diaminohydrolase axis (16 November, 2010) Free

  V Sharma, V Balasubramaniyan, V Sharma, G Metha, A Habtesion, C Turner, R N Dalton, N Davies, R Jalan, R P Mookerjee
• Viral hepatitis: P61 Pegylated interferon and ribavarin combination therapy achieves hepatitis E virus clearance in chronic hepatitis E virus/human immunodeficiency virus co-infection (16 November, 2010) Free

  H Dalton, R Bendall, F Keane, R Neale, R Tedder, S Ijaz
• Viral hepatitis: P62 Bacterial translocation in human immunodeficiency virus-infected patients with hepatitis C virus-related cirrhosis: implication in haemodynamic alterations and mortality (16 November, 2010) Free

  M Montes de Oca, M Coello Mercedes, S C M Jose, R Claudio, T Alberto, V Antonio, F G Clotilde, C Sara, G G J Antonio
• Viral hepatitis: P63 Neurological sequelae of acute and chronic HEV genotype 3 infection (16 November, 2010) Free

  H Dalton, N Kamar, H R Dalton, R Bendall, F Keane, J M Peron, P Cintas, L Pruhomme, J M Mansuy, L Rostaing, S Ijaz, J Izopet
• Viral hepatitis: P64 Hepatitis B virus upregulates hepatocyte expression of PD-L1 to evade hepatoxic adaptive immune responses (16 November, 2010) Free

  S Phillips, A Evans, A Riva, R Williams, N Naoumov, S Chokshi
• Viral hepatitis: P65 Failure to control hepatitis B virus replication despite control of human immunodeficiency virus replication in co-infected patients on tenofovir-containing ART regimen cause for concern in hepatitis B virus monoinfection? (16 November, 2010) Free

  D Joshi, K Childs, I Carey, M Bruce, M Al-Freah, M Horner, P Harrison, A Suddle, K Agarwal, C Taylor
• Viral hepatitis: P66 SVR with telaprevir, peginterferon alfa-2A and ribavirin in HCV patients with well-characterised prior null response, partial response, viral breakthrough or relapse after peginterferon+ ribavirin (16 November, 2010) Free

  G Dusheiko, T Berg, J M Pawlotsky, P Ferenci, S Zeuzem, A J Muir, F Poordad, M L Shiffman, J Heathcote, H Reesink, N Adda, J G McHutchison
• Viral hepatitis: P67 Combined innate and adaptive immune responses are needed to control hepatitis B virus replication in children with infancy-acquired infection (16 November, 2010) Free

  I Carey, A Mendes, S Bansal, G Mieli-Vergani, D Vergani
• Viral hepatitis: P68 PACIFIC: a phase III, randomised, multicentre, dose escalation, efficacy and safety study examining the effects of treatment with peginterferon alfa-2a in patients with Child's A or B cirrhosis in chronic hepatitis C virus infection (16 November, 2010) Free

  S Tanwar, M Wright, G Foster, S Ryder, P Mills, M Cramp, J Parkes, W Rosenberg
• Viral hepatitis: P69 Hepatitis delta RNA level and genotype, and hepatitis B surface antigen titre predict response to PEG-interferon in the treatment of chronic hepatitis delta virus (16 November, 2010) Free

  S Hughes, I Carey, D Shang, M Horner, M Bruce, I Fletcher, T J S Cross, A Suddle, K Agarwal, P M Harrison
• Viral hepatitis: P70 Can antiviral therapy for hepatitis C reduce the prevalence of HCV among injecting drug user populations? A modelling analysis of its prevention utility (16 November, 2010) Free

  M Hickman, N Martin, P Vickerman, S Hutchinson, D Goldberg, G Foster
• Viral hepatitis: P71 Antiviral treatment of recurrent hepatitis C after liver transplantation—the Newcastle experience (16 November, 2010) Free

  S McPherson, M Hudson, D Sheridan, C Miller, K Baxter, M Bassendine
• Viral hepatitis: P72 Low rates of testing for delta hepatitis amongst a large hepatitis B cohort (16 November, 2010) Free

  B Smith, I Brown, D Muir, P Nutter
• Viral hepatitis: P73 Referral of hepatitis B surface Ag positive patients to specialist hepatology care: need for improvement (16 November, 2010) Free

  B Smith, I Brown, D Muir, P Nutter
• Viral hepatitis: P74 CD161 expressing CD8+ T-cells; elusive players in viral hepatitis (16 November, 2010) Free

  L Walker, Y Kang, M Smith, Y Oo, E Barnes, G Lauer, D H Adams, P Klenerman
• Viral hepatitis: P75 Influence of vitamin D supplementation on outcome in the treatment of chronic hepatitis C (16 November, 2010) Free

  P Southern, P El-Sayed, L Fenton, K Forrester, S Morrea
• Viral hepatitis: P76 Lentiviral vectors co-expressing hepatitis B core and vFLIP induce potent CD8 T-cell and antibody responses in HLA-A2 transgenic mice (16 November, 2010) Free

  D Macdonald, N Brindle, M Whelan, M Maini, M Collins, W Rosenberg
• Viral hepatitis: P77 An anti-viral role for CD4+ T cells is observed in only a minority of patients successfully treated for hepatitis C virus (16 November, 2010) Free

  A Godkin, I Rees, P Mizen, A Gallimore
• Viral hepatitis: P78 Prevalence of viral hepatitis in patients undergoing anti-tuberculosis therapy in West London (16 November, 2010) Free

  S Khan, M Asgheddi, M Abdullah, M O'Donoghue, A Lalvani, L Campbell, M Wickremasinghe, O M Kon
• Viral hepatitis: P79 Hepatitis E virus is highly endemic in South West France (16 November, 2010) Free

  H Dalton, J M Mansuy, R Bendall, F Legrand-Abravanel, J P Calot, N Kamar, M Miedouge, V Ellis, H Rech, F Destruel, H R Dalton, J Izopet
• Viral hepatitis: P80 Antiviral therapy in HCV cirrhotic patients: early on-treatment haematological parameters and genotype predict response (16 November, 2010) Free

  I Carey, A Mendes, D Joshi, A Gera, M Al-Freah, S Knighton, A Suddle, K Agarwal
• Viral hepatitis: P81 Psychiatric side effects of antiviral therapy with pegylated interferon and ribavirin are associated with poor response in children with chronic hepatitis C (16 November, 2010) Free

  I Carey, C Pariante, S Bansal, P Subramaniam, S Tizzard, D Vergani, G Mieli-Vergani
• Viral hepatitis: P82 The use of dry blood spot testing for hepatitis C in injecting drug users attending substance misuse services (16 November, 2010) Free

  J Tait, B Stephens, S O'Keeffe, J Dillon
• Viral hepatitis: P83 Intravenous drug use: not a barrier to achieving a sustained virological (16 November, 2010) Free

  J Dillon, H Jafferbhoy, M Miller, J Tait, S Cleary
• Viral hepatitis: P84 Low rates of nucleos(t)ide-associated adverse events in the long-term experience with entecavir (16 November, 2010) Free

  N Mason, M Manns, U Akarca, T T Chang, W Sievert, S K Yoon, N Tsai, A Min, A Pangerl, S Beebe, M Yu, S Wongcharatrawee
• Viral hepatitis: P85 Cognitive symptoms in chronic hepatitis C infection are associated with impaired cognitive test performance but are unrelated to peripheral markers of cellular immune activation (16 November, 2010) Free

  M Gess, D Forton
• Viral hepatitis: P86 Does genotype predict response to treatment in children perinatally infected with hepatitis B virus (16 November, 2010) Free

  J Sira, E Boxall, S Kaskar, J Workman, D Kelly
• Viral hepatitis: P87 Peripheral markers of immune activation are not associated with depression and cognitive impairment before and during antiviral therapy in chronic hepatitis C infection (16 November, 2010) Free

  M Gess, D Forton
• Viral hepatitis: P88 Follow-up of HCV patients referred to specialist services—where do they all go? (16 November, 2010) Free

  R Mcwilliam, P Dundas, A Fraser
• Transplant: P89 Transarterial chemoembolization as neo-adjuvant therapy pre-transplantation in patients with hepatocellular carcinoma (16 November, 2010) Free

  E Tsochatzis, M Garcovich, L Marelli, G Fede, G Germani, J O'Beirne, A Burroughs
• Transplant: P90 Outcomes of cadaveric split liver transplantation for hepatitis C infected patients. A single centre cohort (16 November, 2010) Free

  M Al-Freah, M A BAl-Freah
• Transplant: P91 Nitisinone treatment reduces the need for liver transplantation in children with tyrosinaemia type 1 and is associated with improved post-transplant renal tubular function (16 November, 2010) Free

  D Bartlett, C Lloyd, D Mirza, P McKiernan, P Newsome
• Transplant: P92 Predictive factors for early cardiac events following liver transplantation (16 November, 2010) Free

  J Leithead, K Kandiah, R Steeds, J W Ferguson
• Transplant: P93 The complex process of risk assessment in liver transplantation: what do second opinions tell us? (16 November, 2010) Free

  A Gera, J O'Grady, M Al-Freah, M Heneghan, V Aluvihare, A Suddle, G Auzinger, A Prachalias, P Srinivasan, N Heaton, J Wendon, K Agarwal
• Transplant: P94 Prevalence and clinical significance of heparin induced thrombocytopaenia in patients transplanted for Budd Chiari syndrome (16 November, 2010) Free

  R Westbrook, D Orr, N Heaton, J Wendon, W Bernal, G Auzinger, J O'Grady, R Patel, A Paglucia, R Arya, G Mufti, M Heneghan
• Transplant: P95 Outcomes of pregnancy following liver transplantation (16 November, 2010) Free

  R Westbrook, A Yeoman, K Agarwal, V Aluvihare, J O'Grady, N Heaton, M Heneghan
• Transplant: P96 Longitudinal changes in renal function in liver transplant recipients: impact of acute kidney injury and the assessment of the decline in estimated glomerular filtration rate over 5 years post liver transplantation (16 November, 2010) Free

  A Slack, M McPhail, R Westbrook, N Heaton, M Heneghan, J O'Grady, V Aluvihare, K Agarwal, A Suddle, G Auzinger, W Bernal, C Willars, J Wendon
• Transplant: P97 Post-liver reperfusion hepatic vein portal gradient pressure measurement and the risk of graft dysfunction in whole liver transplantation (16 November, 2010) Free

  S El-Ghazaly Harb, A Bartlett, H Vilca-Melendez, M Rela, N Heaton
• Transplant: P98 Predictors of early hepatic artery thrombosis after primary liver transplantation: a cohort multi-centre study (16 November, 2010) Free

  M Dawwas, A Gimson
• Transplant: P99 Relation of donor risk index and model for end-stage liver disease score to outcome of elective liver transplantation; a single centre experience (16 November, 2010) Free

  M Al-Freah, M A B Al-Freah, E Dionigi, A Suddle, V Aluvihare, K Agarwal, J Wendon, G Auzinger, J O'Grady, M Rela, M Heneghan, N Heaton, W Bernal
• Transplant: P100 Intrahepatic and system cytokine profiles in acetaminophen-induced acute liver failure: possible mechanism of immuneparesis (16 November, 2010) Free

  H Antoniades, Q Anstee, M Bruce, R Mitry, M Hussain, G Auzinger, C Willars, J Wayel, D Concas, N Heaton, R Goldin, W Bernal, A Quaglia, M Thursz, J Wendon
• Transplant: P101 FK stimulation of hepatitis C virus-specific and nonspecific peripheral blood mononuclear cell of patients on waiting list to evaluate and tailor immunosuppresion before orthotopic liver transplantation (16 November, 2010) Free

  A Perrella, G Ioia, C Esposito, O Cuomo
• Transplant: P102 The utility of radioisotope bone scans in the liver transplant assessment for hepatocellular carcinoma (16 November, 2010) Free

  K Sheikh, V Warbey, J O'Beirne, A Burroughs, D Patch, D Thorburn
• Transplant: P103 Clinical utility of myocardial perfusion imaging in liver transplant assessment patients (16 November, 2010) Free

  J Leithead, K Kandiah, R Steeds, J W Ferguson
• Transplant: P104 Serum ferritin concentration may predict waiting list mortality but not independent of model for end-stage liver disease score: evaluation of a cohort of 422 patients (16 November, 2010) Free

  M Al-Freah, M Al-Freah, M Foxton, W Bernal, G Auzinger, V Aluvihare, A Suddle, K Agarwal, N Heaton, J Wendon, J O'Grady, M Heneghan
• Transplant: P105 Complications of incisional hernia repair after orthotopic liver transplantation (16 November, 2010) Free

  M Hoare, C Callaghan, P Gibbs