Figure 6

Figure 6

Endogenous modulation of (A) visceral pain (rectal pain) and (B) somatic pain (hand pain) using heterotopic foot stimulation in healthy controls (n=69) and patients with irritable bowel syndrome (n=84). Decreased pain inhibition or pain facilitation was seen in patients with irritable bowel syndrome compared with the consistent inhibition in controls. (C) Pain modulation differs significantly between individuals of different ethnicities (rectal pain, n=69). Means and 95% CIs are shown. Reproduced with permission from Wilder-Smith and Robert-Yap.75