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Non-alcoholic fatty liver disease: what's new under the microscope?
  1. Elizabeth M Brunt
  1. Correspondence to Dr Elizabeth M Brunt, Department of Pathology, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8118, St Louis, MO 63110, USA; ebrunt{at}


Pathologist's observations have remained central to the evolution of the field of non-alcoholic fatty liver disease, even with the advent of increasingly effective non-invasive markers of advanced fibrosis. As the field matures, the role of pathology has also shifted from being largely descriptive to being confirmatory and diagnostic, as well as providing semi-quantitative evaluation of specific findings, particularly in therapeutic interventional trials. Some newly appreciated histopathological findings will be discussed in this review.

  • Non-alcoholic fatty liver disease
  • non-alcoholic steatohepatitis
  • liver pathology
  • liver biopsy

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  • Competing interests None.

  • Provenance and peer review Commissioned; externally peer reviewed.