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Antibodies to GP2, the major zymogen granule membrane glycoprotein, in inflammatory bowel diseases
  1. Katrijn Op De Beéck1,
  2. Séverine Vermeire2,
  3. Paul Rutgeerts2,
  4. Xavier Bossuyt1
  1. 1Experimental Laboratory Medicine, Department of Medical Diagnostic Sciences, Katholieke Universiteit Leuven, Belgium
  2. 2Internal Medicine, University Hospitals Leuven, Leuven, Belgium
  1. Correspondence to Dr Xavier Bossuyt, Laboratory medicine University Hospitals Leuven Herestraat 49 CDG7 B-3000 Leuven, Belgium; xavier.bossuyt{at}

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It was with interest that we read the paper by Roggenbuck et al1 in a recent issue of Gut, where GP2, the major zymogen granule membrane glycoprotein, is demonstrated to be the autoantigen of pancreatic antibodies in Crohn's disease. The authors concluded that quantification of this novel Crohn's disease-specific marker could significantly improve the serological diagnosis of inflammatory bowel disease. A commercial assay for the detection of anti-GP2 antibodies has recently become available (Generic Assays, Dahlewitz/Berlin). In the present paper, we evaluated this assay on a large well-characterised study population.

The patient cohort has been previously described2 and consisted of 164 patients with Crohn's disease, 118 patients with ulcerative colitis, and 75 control patients with other gastrointestinal diseases (non-inflammatory bowel disease diarrhoeal illnesses). One hundred blood donors were included as well. The diagnosis of ulcerative coliltis or Crohn's disease was based on accepted clinical …

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  • Funding This research has been funded by the Fund for Scientific Research – Flanders. XB is a senior clinical investigator of the Fund for Scientific Research – Flanders.

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the University Hospitals, Leuven.

  • Provenance and peer review Not commissioned; not externally peer reviewed.

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    Dirk Roggenbuck Dirk Reinhold Thomas Wex Ulrike von Arnim Peter Malfertheiner Andreas Sturm Lael Werner Dimitrios P Bogdanos Martin W Laass Karsten Conrad