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Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice
  1. Paul J Grippo1,
  2. Philip S Fitchev2,
  3. David J Bentrem1,
  4. Laleh G Melstrom1,
  5. Surabhi Dangi-Garimella3,
  6. Seth B Krantz1,
  7. Michael J Heiferman1,
  8. Chuhan Chung4,
  9. Kevin Adrian1,
  10. Mona L Cornwell2,
  11. Jan B Flesche5,
  12. Sambasiva M Rao6,
  13. Mark S Talamonti2,
  14. Hidayatullah G Munshi3,
  15. Susan E Crawford2
  1. 1Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
  2. 2Department of Surgery, NorthShore University Research Institute, Evanston, Illinois, USA
  3. 3Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
  4. 4Section of Digestive Diseases, Department of Medicine, Yale University School of Medicine, West Haven, Connecticut, USA
  5. 5The Medical School at Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany
  6. 6Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
  1. Correspondence to Dr Paul Grippo, Robert H Lurie Comprehensive Cancer Center, Northwestern University, 303 E. Superior St., Lurie 3-105, Chicago, IL 60611; p-grippo{at}northwestern.edu

Footnotes

  • An additional figure is published online only. To view this file please visit the journal online (http://dx.doi.org/10.1136/gutjnl-2011-300821).

  • Funding The research described herein was generously supported by funds provided by the Barnum Foundation and Zell Family Foundation at the Northwestern University, the Nathan and Isabel Miller Family Foundation, the IDP Foundation, NIH R01-CA126888 (HGM) and NIH R01-CA64239 (SEC).

  • Competing interests None.

  • Patient consent The Northwestern University IRB has consent forms signed by patients/guardians for the use of blood and tissue samples.

  • Ethics approval Northwestern University IRB.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • An additional figure is published online only. To view this file please visit the journal online (http://dx.doi.org/10.1136/gutjnl-2011-300821).

  • Funding The research described herein was generously supported by funds provided by the Barnum Foundation and Zell Family Foundation at the Northwestern University, the Nathan and Isabel Miller Family Foundation, the IDP Foundation, NIH R01-CA126888 (HGM) and NIH R01-CA64239 (SEC).

  • Competing interests None.

  • Patient consent The Northwestern University IRB has consent forms signed by patients/guardians for the use of blood and tissue samples.

  • Ethics approval Northwestern University IRB.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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