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Role of thiopurine metabolite measurement in the management of autoimmune hepatitis
  1. Safa Al-Shamma,
  2. Simon McLaughlin,
  3. Raymond McCrudden,
  4. Sean Weaver,
  5. Earl Williams
  1. Department of Gastroenterology, The Royal Bournemouth Hospital, Bournemouth, UK
  1. Correspondence to Dr Safa Al-Shamma, Department of gastroenterology, The Royal Bournemouth Hospital, Castle Lane East, Bournemouth BH7 7DW, UK;{at}

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We congratulate Gleeson and Heneghan1 on their detailed and comprehensive guidelines on the management of autoimmune hepatitis (AIH). A noteworthy area for comment relates to the use of azathioprine (AZA) in the management of AIH and the utilisation of thiopurine metabolites to detect hepatotoxicity. As general hepatologists we are most familiar and comfortable with the use of AZA compared with other immunosuppressive agents and feel that every effort should be made to maintain our patients on these well-studied and established agents. …

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  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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