Article Text

Download PDFPDF
Response letter to ‘role of thiopurine metabolite measurement in the management of autoimmune hepatitis’
  1. Dermot Gleeson1,
  2. Michael A Heneghan2
  1. 1Liver Unit, Sheffield Teaching Hospitals, Sheffield UK
  2. 2Institute of Liver Studies, Kings College Hospital, London, UK
  1. Correspondence to Dr Dermot Gleeson, Royal Hallamshire Hospital, Sheffield S10 2JF UK; dermot.gleeson{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

We appreciate the kind comments of Dr Al-shamma and colleagues on our guidelines.

We agree that azathioprine (AZA) plus prednisolone is the best initial regime for autoimmune hepatitis (AIH), and like them, we would encourage perseverance with AZA in patients with minor adverse reactions, which may improve with time.

AZA-induced hepatotoxicity in patients with inflammatory bowel disease (IBD) is usually defined as rises in serum transaminases; most cases have not had histological confirmation. We …

View Full Text


  • Linked article 302077.

  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.

Linked Articles