Article Text

Download PDFPDF
Brain–gut interactions in the regulation of satiety: new insights from functional brain imaging
  1. Qasim Aziz
  1. Centre for Digestive Diseases, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  1. Correspondence to Professor Qasim Aziz, Wingate Institute of Neurogastroenterology, Barts and The London School of Medicine and Dentistry, 26 Ashfield Street, London E1 2AJ, UK; q.aziz{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Since the US army surgeon, William Beaumont, first described the effects of emotion on the gastric function of Alexis St Martin, a Canadian voyager who developed a gastrocutaneous fistula after a gunshot wound,1 considerable progress has been made in our understanding of the human brain–gut axis. Animal studies show that this axis, which comprises neural, hormonal and immune pathways, modulates all aspects of gut function and, perhaps most importantly, also modulates feeding behaviour. Our understanding of the human brain–gut axis has been greatly facilitated by functional brain imaging techniques, which have been used extensively to study visceral pain in health and disease. This work has led to important insights into the visceral pain neuromatrix, and its modulation by psychological and pharmacological factors.2 With advanced brain imaging methods, it has now become possible to study brain–gut communication that occurs through gut peptide hormones, affording an opportunity to understand the central mechanisms of satiety in health and conditions such as obesity and anorexia.

Eating behaviour is not just dictated by metabolic requirements but also by hedonic, psychological, social and environmental influences. Indeed, extremes of eating behaviours leading to obesity and anorexia in the Western world have occurred in the setting of abundance but also a more demanding and stressful environment. While animal studies have improved our basic understanding of the homoeostatic mechanisms of energy balance, translation to humans is limited by the inability to investigate the influence of hedonic and psychological influences on eating behaviour. This limitation is now being overcome through exciting recent brain imaging studies in humans, which are demonstrating a network of brain areas that are activated in response to nutrient ingestion, food cues and orexigenic and anorexigenic gut peptides. …

View Full Text


  • Competing interests None.

  • Provenance and peer review Commissioned; externally peer reviewed.

Linked Articles