Proteases play a decisive role in health and disease. They fulfil diverse functions and have been associated with the pathology of gastrointestinal disorders such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). The current knowledge focuses on host-derived proteases including matrix metalloproteinases, various serine proteases and cathepsins. The possible contribution of bacterial proteases has been largely ignored in the pathogenesis of IBD and IBS, although there is increasing evidence, especially demonstrated for proteases from pathogenic bacteria. The underlying mechanisms extend to proteases from commensal bacteria which may be relevant for disease susceptibility. The intestinal microbiota and its proteolytic capacity exhibit the potential to contribute to the pathogenesis of IBD and IBS. This review highlights the relevance of host- and bacteria-derived proteases and their signalling mechanisms.
- Proteases in IBD and IBS
- bacterial proteases
- proteolytic activity in intestinal disorders
- enteric nervous system
- nervous control of intestinal functions
- bacterial interactions
- signal transduction
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NS and KM are joint first authors.
Funding This work was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft) grant GRK 1482 and the European Union grant FP7 Intestinal Proteases: Opportunity for Drug Discovery (IPODD).
Competing interests None.
Provenance and peer review Not commissioned; externally peer reviewed.