Photo by Katerina Tsilingiri; original magnification 10x. Haematoxylin/eosin staining of a sample taken from a colonic Crohn's Disease (CD) patient. Non canonical villi or crypt structures are often observed in samples from CD patients, as there is extensive inflammation and oedema in the lamina propria region. This causes the villi or crypts to undergo significant changes both in orientation and in 3D structure. This image is a perfect cover for the February edition of Gut!