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Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease
  1. Michael Schumann1,
  2. Dorothee Günzel2,
  3. Nataly Buergel1,
  4. Jan F Richter2,
  5. Hanno Troeger1,
  6. Claudia May1,
  7. Anja Fromm1,2,
  8. Detlef Sorgenfrei2,
  9. Severin Daum1,
  10. Christian Bojarski1,
  11. Martine Heyman3,
  12. Martin Zeitz1,
  13. Michael Fromm2,
  14. Joerg-Dieter Schulzke1,4
  1. 1Department of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité Berlin, Berlin, Germany
  2. 2Institute of Clinical Physiology, Campus Benjamin Franklin, Charité Berlin, Berlin, Germany
  3. 3INSERM, U989, Interactions of the Intestinal Epithelium with the Immune System, Université Paris Descartes, Paris Cedex 15, France
  4. 4Department of General Medicine, Campus Benjamin Franklin, Charité Berlin, Berlin, Germany
  1. Correspondence to Professor Dr Joerg-Dieter Schulzke, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie, 12200 Berlin, Germany; joerg.schulzke{at}charite.de

Footnotes

  • Funding Supported by Deutsche Forschungsgemeinschaft (Schu 2389/1-1 and FOR721/2 TP2).

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Ethic committee Charité Benjamin Franklin (#227-44).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Funding Supported by Deutsche Forschungsgemeinschaft (Schu 2389/1-1 and FOR721/2 TP2).

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Ethic committee Charité Benjamin Franklin (#227-44).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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