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- Inflammatory mediators
- intestinal T cells
- inflammatory mechanisms
- inflammatory bowel disease
- T lymphocytes
- inflammatory cells
I read with interest the study by Leiper and colleagues,1 and the authors should be commended for initiating this investigator-driven study. However, I beg to differ with the conclusion that reads ‘Rituximab has no significant effect on inducing remission in moderately active UC [ulcerative colitis] not responding to oral steroids.’
The authors state that the sample-size calculations were based on 80% power for excluding, at p<0.05, an 80% remission rate with active treatment compared with a predicted 25% placebo remission rate …
Competing interests None.
Provenance and peer review Not commissioned; internally peer reviewed.