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  1. K S Boparai1,2,
  2. J B Reitsma3,
  3. E Dekker1,2
  1. 1Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
  2. 2Department of Hepatology, Academic Medical Center, Amsterdam, The Netherlands
  3. 3Department of Clinical Epidemiology & Biostatistics, Academic Medical Center, Amsterdam, The Netherlands
  1. Correspondence to Dr Evelien Dekker, Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; e.dekker{at}

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Patients with hyperplastic polyposis syndrome (HPS) harbour multiple colorectal hyperplastic polyps and are at risk of developing colorectal cancer (CRC).1 2 In two recent studies from our study group, we described the risk of CRC in patients with HPS during follow-up and the RR of CRC/polyps in first-degree relatives (FDRs) of patients with HPS compared to the general population.1 2 In reaction to our manuscripts, Orlowska3 recommends that a distinction be made between sessile serrated adenomas and traditional serrated adenomas. We agree with this remark, considering that these serrated polyp subtypes differ in histological and geographical characteristics and in molecular profiles.4 Considering that both studies from our group involved …

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  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.