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Stem cell transplantation in neurodegenerative disorders of the gastrointestinal tract: future or fiction?
  1. Subhash Kulkarni,
  2. Laren Becker,
  3. Pankaj Jay Pasricha
  1. Division of Gastroenterology and Hepatology, Stanford University, School of Medicine, Stanford, California, USA
  1. Correspondence to Pankaj Jay Pasricha, Division of Gastroenterology and Hepatology, M211, Stanford University, School of Medicine, Stanford, CA 94305, USA; pasricha{at}


Current advances in our understanding of stem and precursor cell biology and in the protocols of stem cell isolation and transplantation have opened up the possibility of transplanting neural stem cells for the treatment of gastrointestinal motility disorders. This review summarises the current status of research in this field, identifies the major gaps in our knowledge and discusses the potential opportunities and hurdles for clinical application.

  • Enteric nervous system
  • ENS disorders
  • stem cells
  • transplantation
  • challenges
  • enteric nervous system
  • enteric neuromuscular disease
  • enteric neurones
  • neurogastroenterology
  • stem cells

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  • Funding NIDDK (1R01DK080920).

  • Competing interests None.

  • Provenance and peer review Commissioned; externally peer reviewed.