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- Ulcerative colitis
- mucosal healing
- inflammatory bowel disorders
- IBD basic research
- 6-mercaptopurine
- bacterial translocation
- IBD
- thiopurine methyltransferase
- antibacterial peptide
- IBD models
- azathioprine
- IBD clinical
- crohn's disease
- TNF-alpha
- ulcerative colitis
We read with great interest the paper by D'Haens and Ochsenkühn about the importance of mucosal healing (MH) in ulcerative colitis (UC).1 MH is considered to be a reliable indicator of treatment efficacy and a prognostic marker in UC. Since UC is classically described as a mucosal disease, as opposed to Crohn's disease (CD), MH seems the perfect therapeutic goal. In CD, it is accepted that treatment should go beyond symptomatic control and target the progressive course of the disease with reduction in bowel damage, prevention of complications and maintenance of gastrointestinal (GI) physiology. For UC, these goals have translated, for most investigators, in …
Footnotes
Competing interests None.
Provenance and peer review Not commissioned; internally peer reviewed.