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Altered gut microbiota composition in immune-impaired Nod2−/− mice
  1. Stanislas Mondot1,2,
  2. Frédérick Barreau3,
  3. Ziad Al Nabhani3,
  4. Monique Dussaillant3,
  5. Karine Le Roux1,2,
  6. Joël Doré1,2,
  7. Marion Leclerc1,2,
  8. Jean-Pierre Hugot3,
  9. Patricia Lepage1,2
  1. 1INRA, Micalis UMR1319, Domaine de Vilvert, Jouy-en-Josas, France
  2. 2AgroParisTech, Micalis UMR1319, Jouy-en-Josas, France
  3. 3UMR843 INSERM, Université Sorbonne Paris Cité-Diderot, Hôpital Robert Debré, Paris, France
  1. Correspondence to Patricia Lepage, INRA, MICALIS UMR1319, Domaine de Vilvert, 78352 Jouy-en-Josas, Cedex, France; patricia.lepage{at}

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We read with great interest the recently published study by Rehman and colleagues.1 Investigating microbial diversity on faecal and ileal samples from 48 mice using Sanger and 454 techniques, Rehman et al detected increased percentages of Bacteroidetes in the faeces of adult Nod2−/− mice, whereas Firmicutes levels were significantly higher only in the ileum of Nod2−/− mice.

Since we demonstrated that antibiotic …

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  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.