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Luminal GI
Helicobacter pylori eradication and MALT lymphoma in Japan
H pylori infection plays a causative role in the development of gastric MALT lymphoma and its eradication leads to a complete remission of disease in the majority of subjects. However, large-scale long-term follow-up outcome after the eradication therapy is still limited, particularly with regard to relapse or progression and survival. In this issue of Gut, Nakamura et al conducted one of the largest studies with the longest follow-up in Japan. Four hundred twenty patients with gastric low-grade MALT lymphoma who had undergone successful H pylori eradication and been followed up for at least 3 years were registered from 21 participating institutes. Three hundred twenty-three patients (77%) responded to H pylori eradication. The excellent long-term clinical outcome of gastric MALT lymphoma after H pylori eradication was confirmed by the follow-up study ranging from 3.0 to 14.6 years (mean 6.5 years, median 6.04 years); the probabilities of freedom from treatment failure, overall survival and event-free survival after 10 years were 90%, 95% and 86%, respectively (see figure 1). A logistic regression analysis showed that absence of H pylori, submucosal invasion determined by endoscopic ultrasonography and t(11;18)/API2-MALT1 were independent predictors of resistance to H pylori eradication (see page 507).
Kaplan–Meier curves of 420 patients with gastric MALT lymphoma after Helicobacter pylori eradication showing event-free survival.
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Linked Articles
- Hepatology
- GI neoplasia
- Helicobacter pylori
- Pancreas
- Hepatology