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As acute kidney injury (AKI) has not been formally defined in patients with cirrhosis, members of the Acute Dialysis Quality Initiative and the International Club of Ascites formed a working group in March 2010 to discuss the definition of renal dysfunction (acute and chronic) in patients with cirrhosis. The final consensus proposal of the working party was to accept the definition of AKI in cirrhosis as an increase in serum creatinine (SCr) of >50% from baseline or a rise in SCr of >26.4 mmol/l (>0.3 mg/dl) in <48 h, irrespective of whether the cause of the acute deterioration in renal function is related to a functional or structural disorder.1 It was further agreed that these new empirical diagnostic criteria of AKI for cirrhosis will be validated to determine whether these smaller increases in SCr are associated with poor outcomes.
Competing interests None.
Patient consent Since this was a retrospective and observational study that did not evaluate a specific therapeutic or prophylactic intervention, patient written consent was considered not to be necessary.
Ethics approval Since this was a retrospective and observational study that did not evaluate a specific therapeutic or prophylactic intervention, study approval was waived by the ethical committee of our hospital according to institutional guidelines.
Provenance and peer review Not commissioned; externally peer reviewed.
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