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Studies on factors predicting GORD response to proton-pump inhibitors: NERD subpopulations need to be analysed separately
  1. Edoardo Savarino,
  2. Patrizia Zentilin,
  3. Vincenzo Savarino
  1. Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
  1. Correspondence to Dr Edoardo Savarino, Cattedra di Gastroenterologia, Università di Genova, Viale Benedetto XV, 16132 Genova, Italy; esavarino{at}

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We read with interest the paper by Zerbib et al1 on the factors predicting the response of patients with gastro-oesophageal reflux disease (GORD) to proton pump inhibitors (PPIs) therapy and believe that the results they obtained must be interpreted with caution.

The French authors concluded that multivariate analysis, including both clinical and physiological parameters, did not identify any reflux pattern associated with PPI failure. This is at variance with many previous findings, which have clearly shown that an increased oesophageal acid exposure is a robust predictor of reflux response to PPIs. We believe that the surprising result achieved by Zerbib et al is probably due to the fact …

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  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.