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Comparison of MRI with liver-specific contrast agents and multidetector row CT for the detection of hepatocellular carcinoma: a meta-analysis of 15 direct comparative studies
  1. Lihua Chen1,2,
  2. Lin Zhang1,
  3. Jing Bao3,
  4. Jiuquan Zhang1,
  5. Chuanming Li1,
  6. Yunbao Xia2,
  7. Xuequan Huang1,
  8. Jian Wang1
  1. 1 Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, China
  2. 2 Department of Radiology, Taihu Hospital, Wuxi, Jiangsu, China
  3. 3 Molecular Biology Lab, Wuxi Center for Disease Control and Prevention, Wuxi, Jiangsu, China
  1. Correspondence to Dr Jian Wang, Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; wangjian_811{at}

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We read with great interest the paper by Tremosini et al 1 which prospectively assessed the diagnostic performance of a panel of markers (glypican 3, heat shock protein 70, and glutamine synthetase) for small (<20 mm) hepatocellular carcinoma (HCC) in patients with cirrhosis. This study showed that the panel of markers is a useful diagnostic approach for the diagnosis of small HCC. It had a high specificity (100%) but a relatively low sensitivity (60%) when at least two of the markers (regardless of which) were positive. To diagnose HCC, some useful, non-invasive imaging tests, such as CT and MRI, can also be used. The guidelines recently updated by the American Association for the Study of Liver Diseases (AASLD) state that a non-invasive diagnosis of HCC can be made if a lesion >10 mm has a typical vascular enhancement pattern in …

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  • LC and LZ are co-first authors.

  • Contributors Conceived and designed the experiments: LC, JW. Performed the experiments: LC, LZ. Analysed the data: LC, LZ, JB, JZ, CL, YX, XH, JW. Contributed reagents/materials/analysis tools: LC, LZ, JZ, JB, CL, YX, XH. Wrote the paper: LC, LZ. Responsible for research infrastructure: JW.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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