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- Hepatobiliary Radiology
- Hepatocellular Carcinoma
- Computer Tomography
- Magnetic Resonance Imaging
We read with great interest the paper by Tremosini et al 1 which prospectively assessed the diagnostic performance of a panel of markers (glypican 3, heat shock protein 70, and glutamine synthetase) for small (<20 mm) hepatocellular carcinoma (HCC) in patients with cirrhosis. This study showed that the panel of markers is a useful diagnostic approach for the diagnosis of small HCC. It had a high specificity (100%) but a relatively low sensitivity (60%) when at least two of the markers (regardless of which) were positive. To diagnose HCC, some useful, non-invasive imaging tests, such as CT and MRI, can also be used. The guidelines recently updated by the American Association for the Study of Liver Diseases (AASLD) state that a non-invasive diagnosis of HCC can be made if a lesion >10 mm has a typical vascular enhancement pattern in …
LC and LZ are co-first authors.
Contributors Conceived and designed the experiments: LC, JW. Performed the experiments: LC, LZ. Analysed the data: LC, LZ, JB, JZ, CL, YX, XH, JW. Contributed reagents/materials/analysis tools: LC, LZ, JZ, JB, CL, YX, XH. Wrote the paper: LC, LZ. Responsible for research infrastructure: JW.
Competing interests None.
Provenance and peer review Not commissioned; externally peer reviewed.