Table of contents

Original articles

Stomach

• Original article: Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors (23 February, 2012) Free

  Wataru Shibata, Hiroshi Ariyama, Christoph Benedikt Westphalen, Daniel L Worthley, Sureshkumar Muthupalani, Samuel Asfaha, Zinaida Dubeykovskaya, Michael Quante, James G Fox, Timothy C Wang

Inflammatory bowel disease

• Original article: Endoscopic improvement of mucosal lesions in patients with moderate to severe ileocolonic Crohn's disease following treatment with certolizumab pegol (23 April, 2012)

  Xavier Hébuterne, Marc Lémann, Yoram Bouhnik, Olivier Dewit, Jean-Louis Dupas, Michael Mross, Geert D'Haens, Krassimir Mitchev, Étienne Ernault, Séverine Vermeire, Hedia Brixi-Benmansour, Tom G Moreels, Jean-Yves Mary, Philippe Marteau, Jean-Frédéric Colombel
• Original article: Protective role of macrophage-derived ceruloplasmin in inflammatory bowel disease (16 February, 2012)

  Bakytzhan Bakhautdin, Maria Febbraio, Esen Goksoy, Carol A de la Motte, Muhammet F Gulen, Erin Patricia Childers, Stanley L Hazen, Xiaoxia Li, Paul L Fox

Gut microbiota

• Original article: Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity (16 February, 2012)

  Eileen F Murphy, Paul D Cotter, Aileen Hogan, Orla O'Sullivan, Andy Joyce, Fiona Fouhy, Siobhan F Clarke, Tatiana M Marques, Paul W O'Toole, Catherine Stanton, Eamonn M M Quigley, Charlie Daly, Paul R Ross, Robert M O'Doherty, Fergus Shanahan

Neurogastroenterology

• Original article: Nerve activity recordings in routine human intestinal biopsies (2 March, 2012)

  Carla Cirillo, Jan Tack, Pieter Vanden Berghe

Endoscopy

• Original article: Factors determining the quality of screening colonoscopy: a prospective study on adenoma detection rates, from 12 134 examinations (Berlin colonoscopy project 3, BECOP-3) (22 March, 2012)

  Andreas Adler, Karl Wegscheider, David Lieberman, Alireza Aminalai, Jens Aschenbeck, Rolf Drossel, Michael Mayr, Michael Mroß, Mathias Scheel, Andreas Schröder, Katharina Gerber, Gabriela Stange, Stephanie Roll, Ulrich Gauger, Bertram Wiedenmann, Lutz Altenhofen, Thomas Rosch
• Original article: The national colonoscopy audit: a nationwide assessment of the quality and safety of colonoscopy in the UK (1 June, 2012)

  Daniel R Gavin, Roland M Valori, John T Anderson, Mark T Donnelly, J Graham Williams, Edwin T Swarbrick

Colon

• Original article: Ischaemia-induced mucus barrier loss and bacterial penetration are rapidly counteracted by increased goblet cell secretory activity in human and rat colon (25 May, 2012)

  Joep Grootjans, Inca H R Hundscheid, Kaatje Lenaerts, Bas Boonen, Ingrid B Renes, Fons K Verheyen, Cornelis H Dejong, Maarten F von Meyenfeldt, Geerard L Beets, Wim A Buurman
• Original article: Metronomic oral topotecan prolongs survival and reduces liver metastasis in improved preclinical orthotopic and adjuvant therapy colon cancer models (28 April, 2012)

  Christina Hackl, Shan Man, Giulio Francia, Chloe Milsom, Ping Xu, Robert S Kerbel
• Original article:

  Comparison of the clinical prediction model PREMM_1,2,6 and molecular testing for the systematic identification of Lynch syndrome in colorectal cancer

  (16 February, 2012)

  Fay Kastrinos, Ewout W Steyerberg, Judith Balmaña, Rowena Mercado, Steven Gallinger, Robert Haile, Graham Casey, John L Hopper, Loic LeMarchand, Noralane M Lindor, Polly A Newcomb, Stephen N Thibodeau, Sapna Syngal, the Colon Cancer Family Registry
• Original article: A microRNA panel to discriminate carcinomas from high-grade intraepithelial neoplasms in colonoscopy biopsy tissue (25 April, 2012)

  Shuyang Wang, Lei Wang, Nayima Bayaxi, Jian Li, Wim Verhaegh, Angel Janevski, Vinay Varadan, Yiping Ren, Dennis Merkle, Xianxin Meng, Xue Gao, Huijun Wang, Jiaqiang Ren, Winston Patrick Kuo, Nevenka Dimitrova, Ying Wu, Hongguang Zhu

Hepatology

• Original article: Randomised study comparing 48 and 96 weeks peginterferon α-2a therapy in genotype D HBeAg-negative chronic hepatitis B (2 August, 2012)

  Pietro Lampertico, Mauro Viganò, Giovan Giuseppe Di Costanzo, Evangelista Sagnelli, Massimo Fasano, Vito Di Marco, Sara Boninsegna, Patrizia Farci, Silvia Fargion, Tiziana Giuberti, Claudio Iannacone, Loredana Regep, Benedetta Massetto, Floriana Facchetti, Massimo Colombo, on behalf of the PegBeLiver Study Group
• Original article: Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation (23 February, 2012)

  Guanhua Xie, Steve S Choi, Wing-Kin Syn, Gregory A Michelotti, Marzena Swiderska, Gamze Karaca, Isaac S Chan, Yuping Chen, Anna Mae Diehl