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- Mice with cirrhosis
- bacterial translocation
- systemic inflammation
- liver cirrhosis
- portal hypertension
We read with interest the article by Wiest et al about spontaneous bacterial peritonitis guidelines.1 The authors point out the relevance of pathological bacterial translocation (BT) from the gut to mesenteric lymph nodes (MLN) as the pathophysiological hallmark of spontaneous bacterial peritonitis in cirrhosis, and the need of further research in the factors involved in BT. The study of BT, ascites and related immune system abnormalities in carbon tetrachloride (CCl4) cirrhosis is usually conducted in rats. This model has proved useful for research into the pathogenesis and role of the systemic pro-inflammatory response associated with cirrhosis and its link to BT.2–4 We recently showed that modulation of the immune system response in cirrhotic …
Funding Agustín Albillos received grants from the Spanish Ministry of Health, Instituto de Salud Carlos III (no. PS09/00 485 and PI051871, Ciberehd). Melchor Álvarez-Mon received grants from the Comunidad de Madrid (MITIC-CM S-BIO-0189/2006) and from the Spanish Ministry of Health, Instituto de Salud Carlos III (no. PI08/1890). Ciberehd is funded by the Instituto de Salud Carlos III. María José Borrero is supported by a grant from the Spanish Ministry of Education (BES-2008-003209). PS09/00485, PI051871, MITIC-CM S-BIO-0189/2006, PI08/1890, BES-2008-003209. Experimental studies, Human resources.
Competing interests None.
Provenance and peer review Not commissioned; externally peer reviewed.
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