Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies

Hsiao-Ping Chen; Jeng-Jer Shieh; Chia-Che Chang; Tzu-Ting Chen; Jaw-Town Lin; Ming-Shiang Wu; Jeng-Horng Lin; Chun-Ying Wu

doi:10.1136/gutjnl-2011-301708

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Hepatology

Original article

Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies

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	Abstract	Full	Pdf
Jul 2012	489	96	146
Aug 2012	221	66	61
Sep 2012	128	58	54
Oct 2012	68	38	35
Nov 2012	105	43	54
Dec 2012	98	34	38
Jan 2013	121	53	66
Feb 2013	99	44	41
Mar 2013	1824	109	315
Apr 2013	620	73	144
May 2013	431	109	156
Jun 2013	273	92	109
Jul 2013	148	45	57
Aug 2013	154	58	66
Sep 2013	170	39	53
Oct 2013	95	37	52
Nov 2013	115	46	64
Dec 2013	90	30	44
Jan 2014	114	39	47
Feb 2014	68	38	38
Mar 2014	70	39	46
Apr 2014	75	26	30
May 2014	86	31	34
Jun 2014	91	30	45
Jul 2014	90	38	39
Aug 2014	40	30	185
Sep 2014	62	20	20
Oct 2014	92	26	34
Nov 2014	61	23	32
Dec 2014	59	29	30
Jan 2015	60	25	16
Feb 2015	49	22	22
Mar 2015	66	34	33
Apr 2015	76	28	29
May 2015	56	14	26
Jun 2015	38	18	22
Jul 2015	43	12	13
Aug 2015	65	15	13
Sep 2015	49	27	28
Oct 2015	38	23	36
Nov 2015	45	29	23
Dec 2015	74	20	18
Jan 2016	94	13	77
Feb 2016	109	21	19
Mar 2016	79	18	15
Apr 2016	54	15	15
May 2016	56	25	21
Jun 2016	62	15	25
Jul 2016	72	5	7
Aug 2016	66	17	15
Sep 2016	104	10	13
Oct 2016	102	27	21
Nov 2016	61	29	33
Dec 2016	79	21	31
Jan 2017	55	17	18
Feb 2017	89	20	16
Mar 2017	78	20	13
Apr 2017	58	31	28
May 2017	85	22	14
Jun 2017	101	20	17
Jul 2017	145	12	15
Aug 2017	131	19	16
Sep 2017	136	13	8
Oct 2017	209	12	11
Nov 2017	199	19	15
Dec 2017	136	17	14
Jan 2018	209	16	7
Feb 2018	120	12	10
Mar 2018	213	30	21
Apr 2018	168	16	13
May 2018	220	17	15
Jun 2018	208	19	25
Jul 2018	183	14	12
Aug 2018	177	11	12
Sep 2018	157	18	14
Oct 2018	160	11	7
Nov 2018	174	13	7
Dec 2018	156	5	2
Jan 2019	154	8	9
Feb 2019	128	12	14
Mar 2019	142	13	11
Apr 2019	150	24	13
May 2019	167	26	16
Jun 2019	99	8	0
Jul 2019	107	19	14
Aug 2019	151	7	9
Sep 2019	122	14	10
Oct 2019	242	23	16
Nov 2019	161	8	6
Dec 2019	142	8	1
Jan 2020	138	17	10
Feb 2020	178	21	10
Mar 2020	174	11	13
Apr 2020	123	7	6
May 2020	121	9	6
Jun 2020	158	11	11
Jul 2020	123	7	6
Aug 2020	90	7	4
Sep 2020	132	10	18
Oct 2020	143	13	11
Nov 2020	102	3	5
Dec 2020	149	6	9
Jan 2021	127	11	5
Feb 2021	164	12	15
Mar 2021	177	10	3
Apr 2021	120	11	10
May 2021	61	15	14
Jun 2021	15	13	7
Jul 2021	8	7	4
Aug 2021	13	11	7
Sep 2021	15	15	22
Oct 2021	167	14	11
Nov 2021	203	14	8
Dec 2021	225	3	14
Jan 2022	156	11	6
Feb 2022	93	10	5
Mar 2022	217	18	10
Apr 2022	237	12	5
May 2022	246	18	5
Jun 2022	192	16	4
Jul 2022	223	13	7
Aug 2022	217	11	4
Sep 2022	180	19	7
Oct 2022	225	14	4
Nov 2022	371	20	6
Dec 2022	268	17	6
Jan 2023	377	12	3
Feb 2023	186	14	4
Mar 2023	171	12	3
Apr 2023	112	12	4
May 2023	185	5	5
Jun 2023	144	13	4
Jul 2023	197	9	2
Aug 2023	110	7	2
Sep 2023	164	11	4
Oct 2023	238	4	3
Nov 2023	228	32	6
Dec 2023	203	6	4
Jan 2024	216	5	2
Feb 2024	279	8	16
Mar 2024	215	4	5
Total	21662	3087	3520

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