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Identification of novel missense CTRC variants in Japanese patients with chronic pancreatitis
  1. Atsushi Masamune,
  2. Eriko Nakano,
  3. Kiyoshi Kume,
  4. Yoichi Kakuta,
  5. Hiroyuki Ariga,
  6. Tooru Shimosegawa
  1. Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
  1. Correspondence to Dr Atsushi Masamune, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan; amasamune{at}

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We read with great interest the article by Paliwal et al 1 reporting the identification of novel missense variants in the chymotrypsin C (CTRC) gene in patients with tropical pancreatitis and idiopathic chronic pancreatitis (CP) in India. Because there might be geographical differences in the genetics of pancreatitis, we conducted screening of the CTRC gene in Japanese patients with CP. All the eight exons in the CTRC gene were directly sequenced in 506 patients with CP (244 alcoholic, 206 idiopathic, 35 hereditary and 21 familial) and 274 healthy controls as previously described.1 This study was approved by the ethics committee of Tohoku University School of Medicine (article #2012-1-158). We identified five missense variants in patients with CP and one in controls (table 1 …

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  • Contributors AM and TS designed the project. AM, EN, KK, YK and HA performed the experiments. AM and EN wrote the manuscript. AM, EN and KK contributed equally to this work.

  • Financial supports This work was supported in part by a Grant-in-Aid from Japan Society for the Promotion of Science (23591008 and 23659392), and by the Ministry of Health, Labour, and Welfare of Japan.

  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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