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Letter to the editor regarding the report of Duboc et al: connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel disease

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  • Contributors MLJ, SP and CJM designed the study and prepared the letter. All authors have read and approved the final manuscript.

  • Funding This work was supported by Micropharma Limited.

  • Competing interests MLJ and SP acknowledge a conflict of interest as they are cofounders and shareholders of Micropharma. CJM is employed by, and is a shareholder of, Micropharma.

  • Patient consent Obtained.

  • Ethics approval The study was conducted according to the principles of the Declaration of Helsinki. Otherwise healthy hypercholesterolemic adults were recruited from six centres in Prague, Czech Republic. The protocol was approved by the Ethics Committee for multicentric clinical trials of the University Hospital Motol, Czech Republic (FDA/OHRP IORG registration no. IORG0000612). The trial was registered on under study number NCT01341613.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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  • Inflammatory bowel disease
    Henri Duboc Sylvie Rajca Dominique Rainteau David Benarous Marie-Anne Maubert Elodie Quervain Ginette Thomas Véronique Barbu Lydie Humbert Guillaume Despras Chantal Bridonneau Fabien Dumetz Jean-Pierre Grill Joëlle Masliah Laurent Beaugerie Jacques Cosnes Olivier Chazouillères Raoul Poupon Claude Wolf Jean-Maurice Mallet Philippe Langella Germain Trugnan Harry Sokol Philippe Seksik