Article Text

Download PDFPDF
The impact of Crohn's disease genes on healthy human gut microbiota: a pilot study
  1. Christopher Quince1,
  2. Elin E Lundin2,
  3. Anna N Andreasson3,4,
  4. Dario Greco5,
  5. Joseph Rafter5,
  6. Nicholas J Talley6,
  7. Lars Agreus3,
  8. Anders F Andersson7,
  9. Lars Engstrand2,
  10. Mauro D'Amato5
  1. 1 School of Engineering, University of Glasgow, Glasgow, UK
  2. 2 Science for Life Laboratory, Department of Microbiology Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
  3. 3 Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
  4. 4 Stress Research Institute, Stockholm University, Stockholm, Sweden
  5. 5 Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
  6. 6 Department of Medicine, University of Newcastle, Callaghan, New South Wales, Australia
  7. 7 Science for Life Laboratory, Division of Gene Technology, School of Biotechnology, KTH Royal Institute of Technology, Stockholm, Sweden
  1. Correspondence to Dr Mauro D'Amato, Department of Biosciences and Nutrition, Karolinska Institutet, Hälsovägen 7-9, Stockholm 14183, Sweden; mauro.damato{at} or Christopher Quince, School of Engineering, University of Glasgow, Rankine Building, Room 801, Glasgow G12 8LT, UK; christopher.quince{at}

Statistics from

We read with interest the paper by Rehman et al 1 reporting the contribution of Nod2 genotype to the composition of gut microbiota in mice and Crohn's disease (CD) patients. This was followed by a similar description for another CD-predisposing gene, FUT2.2 To date, 163 CD- and ulcerative colitis-risk loci have been identified, and while most of the known causative genes are involved in immune functions and response to infections, their effects on the composition of the gut microbiota are mostly unknown. Studies like those mentioned above are therefore very important, since the relative abundance of specific enteric bacteria has been clearly shown to be of pathogenetic relevance in mouse models of colitis.3 By studying genotype–microbiota correlations in healthy individuals, key information could also be sought for devoid of potentially confounding effects from disease status and therapeutic treatment.

We studied the impact of 30 unequivocal CD-risk loci, each tagged by a single nucleotide polymorphism (SNP), on the mucosa-associated …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.