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Sporadic fundic gland polyps and proximal polyposis associated with gastric adenocarcinoma share a common antral G cell hyperplasia
  1. Paolo Declich1,
  2. Gloria Silvia Arrigoni1,
  3. Barbara Omazzi2,
  4. Massimo Devani2,
  5. Enrico Tavani1,
  6. Alessandro Sioli1,
  7. Stefano Bellone1,
  8. Claudio Gozzini2,
  9. Aurora Bortoli2,
  10. Alberto Prada2
  1. 1Service of Pathology, Rho Hospital, Rho, Italy
  2. 2Division of Gastroenterology and Gastrointestinal Endoscopy, Rho Hospital, Rho, Italy
  1. Correspondence to Dr Paolo Declich, Service of Pathology, Rho Hospital, Corso Europa n. 250, Rho I-20017, Italy; paolo.declich{at}

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We read with great interest the article by Worthley et al1 that recently appeared in your Journal, and the subsequent letter on the same subject.2 We would like to make some comments on this interesting topic.

Worthley et al reported a new autosomal dominant syndrome that they named gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). GAPPS appears to be characterised by proximal gastric polyposis, particularly of the fundic gland type that often displays low and high grade dysplasia with early development of gastric cancer. These patients showed no evidence of colonic polyps, and other genetic syndromes were excluded. Yanaru-Fujisawa et al reported a further family with GAPPS.

So far, dysplasia has been described …

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  • Competing interests None.

  • Ethics approval Comitato etico AO salvini, Garbagnate Milanese.

  • Provenance and peer review Not commissioned; externally peer reviewed.