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Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα
  1. Caroline Swan1,
  2. Nathalie P Duroudier1,
  3. Eugene Campbell2,
  4. Abed Zaitoun3,
  5. Margaret Hastings4,
  6. George E Dukes5,
  7. Joanne Cox5,
  8. Fiona M Kelly5,
  9. Jonathan Wilde5,
  10. Mark G Lennon5,
  11. Keith R Neal6,
  12. Peter J Whorwell4,
  13. Ian P Hall1,
  14. Robin C Spiller2
  1. 1Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK
  2. 2NIHR Biomedical Research Unit, Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK
  3. 3Department of Histopathology, Nottingham University Hospitals, Nottingham, UK
  4. 4Department of Gastroenterology, University of South Manchester, Wythenshawe Hospital, Manchester UK
  5. 5GSK Research and Development Ltd, GlaxoSmithKline, Harlow, UK
  6. 6Department of Public Health Medicine and Epidemiology, University of Nottingham, Nottingham, UK
  1. Correspondence to Professor Robin C Spiller, NIHR Biomedical Research Unit, Nottingham Digestive Diseases Centre, University of Nottingham, University Hospital Nottingham, Queens Medical Centre, E Floor West Block, NG7 2UH, UK; robin.spiller{at}nottingham.ac.uk

Footnotes

  • CS and ND contributed equally to the manuscript.

  • Funding Educational grant from GlaxoSmithKline, grant number: GRGC Ref No: 00474.

  • Competing interests The study was an investigator-initiated study funded by GlaxoSmithKline who supported the project both financially and by performing the array analyses and confirmatory PCR analyses on the rectal biopsies. All subjects received this information prior to study entry. The genetic analyses and write up was performed by the investigators independent of the funder. The Nottingham Biomedical Research Unit is supported by a grant from the National Institute for Health Research. No other conflicts of interest.

  • Ethics approval Approval provided by theNottingham NHS Research Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement We have uploaded the Affymatrix data to a public access database GEO, accession number (GSE36701) which will be available to all from October 2012.

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Footnotes

  • CS and ND contributed equally to the manuscript.

  • Funding Educational grant from GlaxoSmithKline, grant number: GRGC Ref No: 00474.

  • Competing interests The study was an investigator-initiated study funded by GlaxoSmithKline who supported the project both financially and by performing the array analyses and confirmatory PCR analyses on the rectal biopsies. All subjects received this information prior to study entry. The genetic analyses and write up was performed by the investigators independent of the funder. The Nottingham Biomedical Research Unit is supported by a grant from the National Institute for Health Research. No other conflicts of interest.

  • Ethics approval Approval provided by theNottingham NHS Research Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement We have uploaded the Affymatrix data to a public access database GEO, accession number (GSE36701) which will be available to all from October 2012.

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