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We read with great interest the recent study by Dewulf and coworkers1 reporting encouraging results on a prebiotic-based dietary intervention trial in obese patients. This work enlightens that even subtle changes in the gut microbiota may influence the metabolomic signature both inside and outside the gut. Interplay among diet, immunity and microbial and host metabolism results in a complex multidirectional signalling that is critical in the maintenance of a healthy gut functionality, reducing risks for inflammatory bowel diseases and metabo-inflammation states associated with obesity.2 ,3 In parallel, the ‘omics’ era has produced many observations associated with disease states,4 and the correlation among the presence, absence or specific ratios of certain bacterial phyla, orders or genera can be considered as a strategy to directly or indirectly manipulate the microbiome. However, a clear causal molecular link between a specific microbial community and a specific metabolic or immune profile is …
Contributors BF and JB acquired data; BF prepared the letter with the help of DM and GJ. All authors have read and approved the final manuscript.
Funding This work was supported by a grant from the French Research Ministry (ANR-10-ALIA-016 Surfing).
Competing interests DM is employed by the French dairy industry. None of the coauthors have any disclosures and competing financial interest to declare.
Provenance and peer review Not commissioned; externally peer reviewed.
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