Cumulative viral evolutionary changes in chronic hepatitis B virus infection precedes hepatitis B e antigen seroconversion

Yan Cheng; Stephane Guindon; Allen Rodrigo; Lin Ying Wee; Masafumi Inoue; Alex J V Thompson; Stephen Locarnini; Seng Gee Lim

doi:10.1136/gutjnl-2012-302408

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Hepatology

Original article

Cumulative viral evolutionary changes in chronic hepatitis B virus infection precedes hepatitis B e antigen seroconversion

Authors

Yan Cheng Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore PubMed articles Google scholar articles
Stephane Guindon Department of Statistics, University of Auckland, Auckland, New Zealand PubMed articles Google scholar articles
Allen Rodrigo Department of Biology, National Evolutionary Synthesis Center, Duke University, Durham, North Carolina, USA PubMed articles Google scholar articles
Lin Ying Wee Department of Statistics, University of Auckland, Auckland, New Zealand PubMed articles Google scholar articles
Masafumi Inoue Experimental Therapeutic Center, Agency for Science, Technology and Research, Singapore PubMed articles Google scholar articles
Alex J V Thompson Research and Molecular Development, Victorian Infectious Diseases Reference Laboratory, Monash University, Melbourne, Australia PubMed articles Google scholar articles
Stephen Locarnini Research and Molecular Development, Victorian Infectious Diseases Reference Laboratory, Monash University, Melbourne, Australia PubMed articles Google scholar articles
Seng Gee Lim Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore Department of Gastroenterology and Hepatology, National University Health System, Singapore, Singapore PubMed articles Google scholar articles

Correspondence to Professor Seng Gee Lim, Department of Gastroenterology and Hepatology, National University Health System, Tower Block level 10, 1E Kent Ridge Road, Singapore 119228, Singapore; mdclimsg{at}nus.edu.sg

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Citation

Cheng Y, Guindon S, Rodrigo A, et al

Cumulative viral evolutionary changes in chronic hepatitis B virus infection precedes hepatitis B e antigen seroconversion

Gut 2013;62:1347-1355.

Publication history

Received February 27, 2012
Revised November 16, 2012
Accepted November 22, 2012
First published December 15, 2012.

Online issue publication

August 05, 2013

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