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Association of Helicobacter pylori seropositivity with all-cause mortality: fact or fiction?
  1. Palaniappan Manickam1,
  2. Prasad Gunasekaran2,
  3. Rajeev Sudhakar2,
  4. Vikas Veeranna3,
  5. Luis Afonso3
  1. 1 Division of Gastroenterology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan, USA
  2. 2 Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA
  3. 3 Division of Cardiology, Wayne State University, Detroit, Michigan, USA
  1. Correspondence to Dr Palaniappan Manickam, Division of Gastroenterology, Oakland University William Beaumont School of Medicine, Royal Oak, MI 48037, USA; Palaniappan.Manickam{at}

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We read the article by Chen et al with great interest and would like to congratulate them on their findings. Their analysis of the data from the National Health and Nutrition Examination Survey (NHANES III) have shown a lack of association between Helicobacter pylori seropositivity and all-cause mortality in patients more than 40 years of age.1 As there is an existing controversy2–4 in this area, evaluation of other large databases is clinically relevant, particularly if the analyses provides congruent data as in this instance, replicating findings that help consolidate the evidence base in the literature. The …

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  • Contributors PM and PG: Hypothesis formulation, statistical analysis, interpretation of data and manuscript drafting. RS and VV: Literature review, study design and critical review of manuscript for intellectual content. LA: Study design, interpretation of data, critical review, editing and final approval of the intellectual content of the manuscript.

  • Funding None.

  • Disclaimer MESA is conducted and supported by the NHLBI in collaboration with the MESA Study Investigators. This manuscript was prepared using the limited access dataset obtained from the NHLBI and does not necessarily reflect the opinions or views of the MESA or the NHLBI.

  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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