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A hyperplastic cause of hyperemesis
  1. Preethi Dasilva,
  2. Neil Rajoriya,
  3. Tom Morgan,
  4. Peter Johnson,
  5. David A Gorard
  1. Gastroenterology Department, Wycombe Hospital, Bucks, UK
  1. Correspondence to Dr David A Gorard, Gastroenterology Department, Wycombe Hospital, Queen Alexandra Road, High Wycombe, Bucks HP11 2TT, UK; david.gorard{at}

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A 46-year-old lady presented with a 3-month history of severe, worsening epigastric discomfort. This pain was associated with increasingly frequent episodes of vomiting. Her repeated vomiting led to weight loss of 6.5 kg. A trial of metoclopramide produced some initial symptomatic relief but its beneficial effects subsequently wore off.

Clinical examination revealed some tenderness in the upper abdomen. Blood tests showed unremarkable haematological and biochemical profiles, with normal inflammatory markers. At upper gastrointestinal endoscopy there was circumferential …

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  • Contributors PD, NR and TM wrote the initial manuscript draft. PJ prepared the histology figure. DAG revised the manuscript. All authors read and approved the manuscript prior to submission.

  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; internally peer reviewed.