Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings

Charlotte R Hedin; Neil E McCarthy; Petra Louis; Freda M Farquharson; Sara McCartney; Kirstin Taylor; Natalie J Prescott; Trevor Murrells; Andrew J Stagg; Kevin Whelan; James O Lindsay

doi:10.1136/gutjnl-2013-306226

Article info

Inflammatory bowel disease

Original article

Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings

Authors

Charlotte R Hedin Diabetes and Nutritional Sciences Division, School of Medicine, King's College London, London, UK Centre for Digestive Diseases, Blizard Institute, Queen Mary University of London, London, UK PubMed articles Google scholar articles
Neil E McCarthy Centre for Digestive Diseases, Blizard Institute, Queen Mary University of London, London, UK PubMed articles Google scholar articles
Petra Louis Microbiology Group, Gut Health Theme, Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen, UK PubMed articles Google scholar articles
Freda M Farquharson Microbiology Group, Gut Health Theme, Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen, UK PubMed articles Google scholar articles
Sara McCartney Department for Gastroenterology and Clinical Nutrition, University College Hospitals NHS Foundation Trust, London, UK PubMed articles Google scholar articles
Kirstin Taylor Department of Medical and Molecular Genetics, King's College London, London, UK PubMed articles Google scholar articles
Natalie J Prescott Department of Medical and Molecular Genetics, King's College London, London, UK PubMed articles Google scholar articles
Trevor Murrells National Nursing Research Unit, Florence Nightingale School of Nursing and Midwifery, King's College London, London, UK PubMed articles Google scholar articles
Andrew J Stagg Centre for Immunology and Infectious Disease, Blizard Institute, Queen Mary University of London, London, UK PubMed articles Google scholar articles
Kevin Whelan Diabetes and Nutritional Sciences Division, School of Medicine, King's College London, London, UK PubMed articles Google scholar articles
James O Lindsay Centre for Digestive Diseases, Blizard Institute, Queen Mary University of London, London, UK Gastroenterology Division, Barts Health NHS Trust, London, UK PubMed articles Google scholar articles

Correspondence to Dr James Lindsay, Barts Health NHS Trust, Endoscopy Unit, The Royal London Hospital, Whitechapel, London E1 1BB, UK; James.Lindsay{at}bartshealth.nhs.uk

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Citation

Hedin CR, McCarthy NE, Louis P, et al

Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings

Gut 2014;63:1578-1586.

Publication history

Received October 9, 2013
Revised November 13, 2013
Accepted December 6, 2013
First published January 7, 2014.

Online issue publication

September 02, 2014

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