Table of contents

Original articles

Oesophagus

• Original article: Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma (11 April, 2013)

  DunFa Peng, TianLing Hu, Mohammed Soutto, Abbes Belkhiri, Alexander Zaika, Wael El-Rifai

Stomach

• Original article: Proton pump inhibitors and the risk of hospitalisation for community-acquired pneumonia: replicated cohort studies with meta-analysis (15 July, 2013)

  Kristian B Filion, Dan Chateau, Laura E Targownik, Andrea Gershon, Madeleine Durand, Hala Tamim, Gary F Teare, Pietro Ravani, Pierre Ernst, Colin R Dormuth, the CNODES Investigators

Gut microbiota

• Original article: Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section (7 August, 2013)

  Hedvig E Jakobsson, Thomas R Abrahamsson, Maria C Jenmalm, Keith Harris, Christopher Quince, Cecilia Jernberg, Bengt Björkstén, Lars Engstrand, Anders F Andersson

Inflammatory bowel disease

• Original article: Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment (6 March, 2013)

  Cornelia Tillack, Laura Maximiliane Ehmann, Matthias Friedrich, Rüdiger P Laubender, Pavol Papay, Harald Vogelsang, Johannes Stallhofer, Florian Beigel, Andrea Bedynek, Martin Wetzke, Harald Maier, Maria Koburger, Johanna Wagner, Jürgen Glas, Julia Diegelmann, Sarah Koglin, Yvonne Dombrowski, Jürgen Schauber, Andreas Wollenberg, Stephan Brand
• Original article: Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease (23 March, 2013)

  Pim J Koelink, Saskia A Overbeek, Saskia Braber, Mary E Morgan, Paul A J Henricks, Mojtaba Abdul Roda, Hein W Verspaget, Simone C Wolfkamp, Anje A te Velde, Caleb W Jones, Patricia L Jackson, J Edwin Blalock, Rolf W Sparidans, John A W Kruijtzer, Johan Garssen, Gert Folkerts, Aletta D Kraneveld
• Original article: East–West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort (20 April, 2013)

  J Burisch, N Pedersen, S Čuković-Čavka, M Brinar, I Kaimakliotis, D Duricova, O Shonová, I Vind, S Avnstrøm, N Thorsgaard, V Andersen, S Krabbe, J F Dahlerup, R Salupere, K R Nielsen, J Olsen, P Manninen, P Collin, E V Tsianos, K H Katsanos, K Ladefoged, L Lakatos, E Björnsson, G Ragnarsson, Y Bailey, S Odes, D Schwartz, M Martinato, G Lupinacci, M Milla, A De Padova, R D'Incà, M Beltrami, L Kupcinskas, G Kiudelis, S Turcan, O Tighineanu, I Mihu, F Magro, L F Barros, A Goldis, D Lazar, E Belousova, I Nikulina, V Hernandez, D Martinez-Ares, S Almer, Y Zhulina, J Halfvarson, N Arebi, S Sebastian, P L Lakatos, E Langholz, P Munkholm, for the EpiCom-group

Intestinal inflammation

• Original article: Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice (21 June, 2013)

  Marina Bersudsky, Lotem Luski, Daniel Fishman, Rosalyn M White, Nadya Ziv-Sokolovskaya, Shahar Dotan, Peleg Rider, Irena Kaplanov, Tegest Aychek, Charles A Dinarello, Ron N Apte, Elena Voronov

Colon

• Original article: Canonical Wnt signals combined with suppressed TGFβ/BMP pathways promote renewal of the native human colonic epithelium (5 July, 2013)

  Amy Reynolds, Natalia Wharton, Alyson Parris, Esther Mitchell, Anastasia Sobolewski, Christy Kam, Loren Bigwood, Ahmed El Hadi, Andrea Münsterberg, Michael Lewis, Christopher Speakman, William Stebbings, Richard Wharton, Kevin Sargen, Richard Tighe, Crawford Jamieson, James Hernon, Sandeep Kapur, Naohide Oue, Wataru Yasui, Mark R Williams
• Original article: Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling (13 June, 2013)

  Jillian L Pope, Ajaz A Bhat, Ashok Sharma, Rizwan Ahmad, Moorthy Krishnan, Mary K Washington, Robert D Beauchamp, Amar B Singh, Punita Dhawan
• Original article: Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis (23 May, 2013)

  Keun Hur, Paloma Cejas, Jaime Feliu, Juan Moreno-Rubio, Emilio Burgos, C Richard Boland, Ajay Goel

Pancreas

• Original article:

  Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas^G12V-driven pancreatic tumourigenesis

  (18 April, 2013)

  Marta Flandez, Jaroslaw Cendrowski, Marta Cañamero, Antonio Salas, Natalia del Pozo, Kristina Schoonjans, Francisco X Real
• Original article: Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation (3 May, 2013)

  Guido von Figura, John P Morris , Christopher V E Wright, Matthias Hebrok

Hepatology

• Original article: Dysregulation of interferon regulatory factors impairs the expression of immunostimulatory molecules in hepatitis C virus genotype 1-infected hepatocytes (20 June, 2013)

  Esther Larrea, Jose-I Riezu-Boj, Rafael Aldabe, Laura Guembe, Itziar Echeverria, Anangi Balasiddaiah, Pablo Gastaminza, María Pilar Civeira, Pablo Sarobe, Jesus Prieto
• Original article: Keratin 19: a key role player in the invasion of human hepatocellular carcinomas (19 August, 2013)

  Olivier Govaere, Mina Komuta, Johannes Berkers, Bart Spee, Carl Janssen, Francesca de Luca, Aezam Katoonizadeh, Jasper Wouters, Léon C van Kempen, Anne Durnez, Chris Verslype, Joery De Kock, Vera Rogiers, Leo A van Grunsven, Baki Topal, Jacques Pirenne, Hugo Vankelecom, Frederik Nevens, Joost van den Oord, Massimo Pinzani, Tania Roskams