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Anti-TNF-α-induced psoriasiform lesions in IBD: an abnormal immune activation or a ‘patchy cutaneous’ immune suppression?

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  • AS, AG, CDeS, FS, AP and VP contributed equally.

  • Contributors FS, AP, VP, LRL, AG, EC, AS and CDeS wrote, revised the manuscript and analysed data. VP and FS performed culturing of the skin biopsies. VA analysed histopathology. MC performed RT-PCR, Bioplex and analysed these data. FP, GC, AC and CDeS performed the dermatological evaluation, gave informed consent to the patient and performed the cutaneous biopsy. MC and EC clinically managed the patient.

  • Funding This work was supported by PRIN 2008 and Fondazione di Ricerca in Medicina.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Catholic University of The Sacred Hearth, Rome, Italy.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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