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An unusual cause of weight loss in a young Caucasian man
  1. Paolo Cecinato1,
  2. Lorenzo Fuccio1,
  3. Elena Sabattini2,
  4. Liboria Laterza1,
  5. Alessandra Caponi1,
  6. Francesco Azzaroli1,
  7. Giuseppe Mazzella1
  1. 1Gastroenterology Unit, S. Orsola-Malpighi Hospital, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
  2. 2Molecular Pathology Laboratory, Hematopathology Section, S. Orsola-Malpighi Hospital, Department of Specialized Diagnostic and Experimental Medicine, University of Bologna, Bologna, Italy
  1. Correspondence to Dr Paolo Cecinato, Gastroenterology Unit, Department of Medical and Surgical Sciences, S. Orsola-Malpighi University Hospital, Bologna 40138, Italy; paolocecinato{at}

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Clinical presentation

A 37-year-old Caucasian male presented to our institution for progressive weight loss and recurrent abdominal pain. An enteral CT performed in another centre showed a diffuse thickening of the duodenal walls suggestive of lymphoma or Crohn’s disease.

Esophagogastroduodenoscopy showed a normal appearance of gastroesophageal mucosa while the duodenal and proximal jejunal mucosa appeared completely covered with pseudo-polypoid lesions with maximum size of 5 mm (figure 1A,B). At the ileocolonoscopy, the colorectal mucosa was diffusely micronodular (figure 1D), while the terminal ileum presented same lesions detected in the duodenum (figure 1C).

Figure 1

Endoscopic view: (A) duodenum, (B) jejunum, (C) ileum, (D) colon.

Enteroscopy confirmed the presence of pseudopolypoid lesions also in the jejunum and ileum, …

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  • Contributors PC wrote the manuscript and prepared the endoscopic figure; LF and FA revised the manuscript; ES prepared the histology figure; LL and AL acquired clinical data; GM supervised the project. All the authors have approved the final draft submitted for publication.

  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.