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Exonic variants affecting pre-mRNA splicing add to genetic burden in chronic pancreatitis

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  • Author note Gene symbols: CFTR, cystic fibrosis transmembrane conductance regulator; CTRC, chymotrypsinogen C; PRSS1, serine protease 1 (human cationic trypsinogen); SPINK1, serine protease inhibitor Kazal type 1 (pancreatic secretory trypsin inhibitor).

  • Contributors SB and MS-T designed and executed the study and wrote the manuscript.

  • Funding These studies were supported by NIH grants R01DK082412, R01DK058088 and R01DK095753 to MS-T.

  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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