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Shanghai fever—a Pseudomonas aeruginosa enteric disease
Shanghai fever, first documented in 1918, is a syndrome comprising fever, diarrhoea and sepsis, and is caused by enteric Pseudomonas aeruginosa infection. Community-acquired cases were subsequently reported in children without pre-existing conditions, primarily from Taiwan, Hong Kong and China. The disease usually leads to serious complications and is associated with high mortality. Sadly our understanding of this disease is still incomplete and its pathogenesis remains unknown. In this issue of Gut, Chuang et al present the most comprehensive study to date on the clinical features of Shanghai fever (table 1) and the host and microbial factors associated with the infection. The data presented offer a glimmer of hope in the fight against this deadly disease.
In colon cancer, it's not just if a gene is mutated, but where, that matters
Cancer in general is viewed as being predominantly a disease that results from alterations in genes. Many of the oncogenes and tumour suppressor genes involved in colorectal cancer have been identified over the last three decades, although the role they play in tumour formation is still being defined. One of the most common tumour suppressor genes mutated in colorectal cancer is FBXW7. FBXW7 …
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