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Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity

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  • Contributors PAH, GAH, DMU and SMB conceived the study. PAH, AMH, GAH and SMB designed the experiments. PAH, JC, AMH, NI, MM and SMB conducted and analysed the experiments. SMB wrote the paper and all authors helped with critical revision of the manuscript for important intellectual content.

  • Funding This work was funded by Tioga Pharmaceuticals Inc. PAH is an NHMRC Australian Biomedical Fellow. AMH is an Australian Research Council Discovery Early Career Research Fellow. SMB is an NHMRC R D Wright Biomedical Fellow.

  • Competing interests SMB and PAH received funding from Tioga Pharmaceuticals Inc. to conduct the study. GAH and DMU are employees of Tioga Pharmaceuticals Inc. JC, AMH, NI and MM have nothing to declare.

  • Ethics approval Experiments were approved by the Animal Ethics Committees of the Institute of Veterinary and Medical Science/SA Pathology and the University of Adelaide.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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