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We read with great interest the leading article by Rosselli et al1 which offers a contemporary perspective to the clinical issue of interpreting progression (and regression) of chronic liver diseases (CLDs).
We fully agree with the view that the histological scoring of fibrosis is a reductive approach to the assessment of CLDs, as it does not fully reflect the complex events involved in the progression to cirrhosis. As suggested by Rosselli et al, a more insightful morphological analysis of liver biopsy should consider other important factors contributing to disease progression/regression, and possibly to cancer development. Angiogenesis represents one of such key factors.
Liver angiogenesis is a pathophysiological process characterised by changes in the phenotype of sinusoidal endothelial cells, which assume the features of capillary endothelial cells. This process, …
Contributors Conception and design: MG, MB. Histological analysis: MG, MP. Acquisition of data: MG, MP, DS, MR, MB. Statistical analysis: LG. Drafting the manuscript: MG and MP. All authors contributed to the critical revision of the manuscript.
Competing interests None.
Ethics approval Ethics Committee.
Provenance and peer review Not commissioned; internally peer reviewed.
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