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Contributors CNB made the original draft of the manuscript and LET and WDL contributed to editing and developing the concepts for the commentary.
Competing interests CNB is supported in part by the Bingham Chair in Gastroenterology. In the past 2 years he has served as a consultant to or been on the advisory boards of Abbvie Canada, Forest Canada, Hospira, Takeda Canada, Bristol Myers Squibb and Vertex Pharmaceuticals and has received a research grant from Abbvie Canada and an unrestricted educational grant from Aptalis Pharmaceuticals. WDL has served on advisory boards for Novartis, Amgen, Genzyme; received unrestricted research grants from Amgen; and received speaker fees from Amgen. LET has served on an advisory board for Merck Canada.
Provenance and peer review Commissioned; internally peer reviewed.