Genetic variation in the lymphotoxin-α (LTA)/tumour necrosis factor-α (TNFα) locus as a risk factor for idiopathic achalasia

Mira M Wouters; Diether Lambrechts; Jessica Becker; Isabelle Cleynen; Jan Tack; Ana G Vigo; Antonio Ruiz de León; Elena Urcelay; Julio Pérez de la Serna; Wout Rohof; Vito Annese; Anna Latiano; Orazio Palmieri; Manuel Mattheisen; Michaela Mueller; Hauke Lang; Uberto Fumagalli; Luigi Laghi; Giovanni Zaninotto; Rosario Cuomo; Giovanni Sarnelli; Markus M Nöthen; Séverine Vermeire; Michael Knapp; Ines Gockel; Johannes Schumacher; Guy E Boeckxstaens

doi:10.1136/gutjnl-2013-304848

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Oesophagus

Original article

Genetic variation in the lymphotoxin-α (LTA)/tumour necrosis factor-α (TNFα) locus as a risk factor for idiopathic achalasia

Authors

Mira M Wouters Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium PubMed articles Google scholar articles
Diether Lambrechts Vesalius Research Center, VIB, Leuven University, Leuven, Belgium Laboratory for Translational Genetics, University of Leuven, Leuven, Belgium PubMed articles Google scholar articles
Jessica Becker Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany Institute of Human Genetics, University of Bonn, Bonn, Germany PubMed articles Google scholar articles
Isabelle Cleynen Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium PubMed articles Google scholar articles
Jan Tack Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium PubMed articles Google scholar articles
Ana G Vigo Immunology and Gastroenterology Departments, Instituto de Investigacion Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain PubMed articles Google scholar articles
Antonio Ruiz de León Immunology and Gastroenterology Departments, Instituto de Investigacion Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain PubMed articles Google scholar articles
Elena Urcelay Immunology and Gastroenterology Departments, Instituto de Investigacion Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain PubMed articles Google scholar articles
Julio Pérez de la Serna Immunology and Gastroenterology Departments, Instituto de Investigacion Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain PubMed articles Google scholar articles
Wout Rohof Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands PubMed articles Google scholar articles
Vito Annese Division of Gastroenterology, IRCCS ‘Casa Sollievo della Sofferenza’ Hospital, San Giovanni Rotondo, Italy Unit of Gastroenterology SOD2, Azienda Ospedaliera Universitaria, Careggi, Firenze, Italy PubMed articles Google scholar articles
Anna Latiano Division of Gastroenterology, IRCCS ‘Casa Sollievo della Sofferenza’ Hospital, San Giovanni Rotondo, Italy PubMed articles Google scholar articles
Orazio Palmieri Division of Gastroenterology, IRCCS ‘Casa Sollievo della Sofferenza’ Hospital, San Giovanni Rotondo, Italy PubMed articles Google scholar articles
Manuel Mattheisen Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany Institute of Human Genetics, University of Bonn, Bonn, Germany Institute for Genomic Mathematics, University of Bonn, Bonn, Germany Department of Biostatistics, Harvard School of Public Health, Boston, USA PubMed articles Google scholar articles
Michaela Mueller Department of Gastroenterology, German Clinic of Diagnostics, Wiesbaden, Germany PubMed articles Google scholar articles
Hauke Lang Department of General, Visceral and Transplant Surgery, University Medical Center of Mainz, Mainz, Germany PubMed articles Google scholar articles
Uberto Fumagalli Department of Gastroenterology, Humanitas Clinical and Research Center—Istituto Clinico Humanitas IRCCS, Milan, Italy PubMed articles Google scholar articles
Luigi Laghi Department of Gastroenterology, Humanitas Clinical and Research Center—Istituto Clinico Humanitas IRCCS, Milan, Italy PubMed articles Google scholar articles
Giovanni Zaninotto Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy PubMed articles Google scholar articles
Rosario Cuomo Gastroenterology Unit, Department of Clinical and Experimental Medicine, Federico II University, Napoli, Italy PubMed articles Google scholar articles
Giovanni Sarnelli Gastroenterology Unit, Department of Clinical and Experimental Medicine, Federico II University, Napoli, Italy PubMed articles Google scholar articles
Markus M Nöthen Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany Institute of Human Genetics, University of Bonn, Bonn, Germany PubMed articles Google scholar articles
Séverine Vermeire Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium PubMed articles Google scholar articles
Michael Knapp Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany PubMed articles Google scholar articles
Ines Gockel Department of General, Visceral and Transplant Surgery, University Medical Center of Mainz, Mainz, Germany PubMed articles Google scholar articles
Johannes Schumacher Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany Institute of Human Genetics, University of Bonn, Bonn, Germany PubMed articles Google scholar articles
Guy E Boeckxstaens Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium PubMed articles Google scholar articles

Correspondence to Dr Mira Wouters, Translational Research Center for Gastrointestinal Disorders, Herestraat 49, O&NI, box 701, Leuven B-3000, Belgium; mira.wouters{at}med.kuleuven.be

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Citation

Wouters MM, Lambrechts D, Becker J, et al

Genetic variation in the lymphotoxin-α (LTA)/tumour necrosis factor-α (TNFα) locus as a risk factor for idiopathic achalasia

Gut 2014;63:1401-1409.

Publication history

Received March 7, 2013
Revised October 23, 2013
Accepted October 25, 2013
First published November 20, 2013.

Online issue publication

April 18, 2016

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